Use and development of statistical mediation techniques to understand the survival gap between males and females with cystic fibrosis

Cystic Fibrosis (CF) is a life limiting genetic disorder affecting over 70,000 people worldwide. It is caused by a mutation in the Cystic Fibrosis Transmembrane Regulator (CFTR) gene which supplies the instructions for the cystic fibrosis transmembrane conductance regulator protein which acts as a channel to transport chloride and bicarbonate ions…