Unveiling the role of a periplasmic lipocalin and a membrane cytochrome in antibiotic heteroresistance of Gram-negative bacteria

The knowledge gap–Treating infections by Gram-negative bacteria is becoming increasingly difficult since these bacteria often show intrinsic high-level resistance to virtually all clinically approved antibiotics. Compounding this problem, many bacteria display heteroresistance, a phenomenon where subpopulations of seemingly isogenic bacteria…