grant
Untangling the effects of anti-amyloid therapy on neurodegeneration and neuroinflammation
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026(TNF)-αA β-42A β42A-beta 42A-beta42AD and related dementiaAD dementiaAD pathologyAD related dementiaAD therapyAD treatmentADRDAbeta-42Abeta42AccelerationAddressAdoptedAdvisory CommitteesAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's therapyAlzheimers DementiaAmyloidAmyloid ProteinsAmyloid SubstanceAmyloid beta-42Amyloid beta42Amyloid β-42Amyloid β42Amyloidβ-42Amyloidβ42AreaAssessment instrumentAssessment toolAstroproteinAutomobile DrivingAβ-42Aβ42BBB disruptionBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBlood VesselsBody TissuesBrainBrain Nervous SystemCachectinCare GiversCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCaregiversCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessClinicalClinical ResearchClinical StudyCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDWI (diffusion weighted imaging)DWI-MRIDataDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderDisturbance in cognitionDrugsEarly identificationEncephalonEnvironmentExtravasationFDA approvedFailureGFA-ProteinGFAPGliaGlial CellsGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsImageImpaired cognitionIndividualInfusionInfusion proceduresInstitutionInsuranceIntercellular FluidInterleukinsInterstitial FluidsK-AwardsK-Series Research Career ProgramsKnowledgeKolliker's reticulumLeakageLeannessLearningLiquid substanceLong-term cohortLongitudinal cohortLongitudinal observational studyMR ImagingMR TomographyMRIMRIsMacrophage-Derived TNFMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMemoryMentorsMentorshipMeta-AnalysisMonitorMonocyte-Derived TNFNMR ImagingNMR TomographyNerve CellsNerve DegenerationNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuroimmuneNeurologistNeurologyNeuron DegenerationNeuronsNon-neuronal cellNonneuronal cellNuclear Magnetic Resonance ImagingParticipantPathologicPatient CarePatient Care DeliveryPatientsPennsylvaniaPermeabilityPharmaceutical PreparationsPhysiciansPlasmaPlasma SerumPositionPositioning AttributePrimary Senile Degenerative DementiaProcessR-Series Research ProjectsR01 MechanismR01 ProgramResearchResearch Career ProgramResearch GrantsResearch MethodologyResearch MethodsResearch Project GrantsResearch ProjectsResearch ResourcesResourcesReticuloendothelial System, Serum, PlasmaSafetyScanningScientistSeverity of illnessSpillageStructureSubcellular ProcessTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTask ForcesTechniquesTestingThinnessTissuesTrainingTumor Necrosis FactorTumor Necrosis Factor-alphaUniversitiesUpregulationVisitWorkZeugmatographyadvisory teamanalyzing longitudinalbio-markersbiologic markerbiomarkerbiophysical modelblood-brain barrier disruptionbloodbrain barrier disruptionbrain volumecare for patientscare of patientscareercaring for patientsclinical efficacyclinical practicecognitive dysfunctioncognitive losscohortcostdMRIdiffusion tensor imagingdisease severitydrivingdrug/agentfluidgray matterhealth care burdenimagingimprovedinfusionsinstructorliquidlong term observational studylongitudinal analysismulti-modalitymultimodalitynerve cementneural degenerationneural imagingneural inflammationneuro-imagingneurodegenerationneurodegenerativeneuroimagingneuroinflammationneuroinflammatoryneurological degenerationneurological imagingneuronalneuronal degenerationneuropathologicneuropathologicalneuropathologypre-clinicalpreclinicalprimary degenerative dementiaresearch and methodsresearch studyresponseresponse to therapyresponse to treatmentsenile dementia of the Alzheimer typeside effectskillsstatisticssubstantia griseatherapeutic responsetherapy responsetreatment responsetreatment responsivenessvascular
Description preview
PROJECT SUMMARY
In this K23 career development award, Dr. Christopher Brown, a cognitive neurologist and Instructor of
Neurology at the University of Pennsylvania, will obtain training in integrating advanced imaging and fluid-
based biomarkers in clinical research studies of Alzheimer’s disease (AD) and related dementias (ADRD). This
project will…
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