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Unravelling the structural features and repair pathways of alcohol and fatty acid-derived DNA interstrand crosslinks

Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
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The metabolism of alcohol and various fatty acids can produce highly reactive aldehydes such as acetaldehyde and trans-4-hydroxynonenal (4-HNE). These can react with the bases in DNA to produce interstrand crosslinks (ICLs) that block DNA replication and if not repaired, can lead to cell death. An inability to repair ICLs is a characteristic of…

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Unravelling the structural features and repair pathways of alcohol and fatty acid-derived DNA interstrand crosslinks — U | Dev Procure