grant
Unravelling Metabolic Plasticity Through Genetic Interaction Mapping.
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AcuteBuffersCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell BodyCellsChromosome MappingClinicalCompensationCulture MediaDNA AlterationDNA Sequence AlterationDrug TherapyDrug resistanceEnzyme GeneEnzymesGene LocalizationGene MappingGene Mapping GeneticsGenesGeneticGenetic AlterationHumanIntermediary MetabolismLibrariesLinkage MappingMalignant CellMalignant NeoplasmsMalignant TumorMapsMetabolicMetabolic ProcessesMetabolismModern ManNetwork AnalysisNutrientNutrient availabilityOther GeneticsOutcomePathway AnalysisPathway interactionsPharmacological TreatmentPharmacotherapyPhysiologicPhysiologicalRegulationSequence AlterationTherapeuticTotal Human and Non-Human Gene Mappingbiomarker identificationcancer biomarkerscancer cellcancer cell metabolismcancer markerscancer metabolismclustered regularly interspaced short palindromic repeats screencombinatorialdesigndesigningdrug interventiondrug resistantdrug treatmentgenetic mappinggenomic alterationgrowth mediaidentification of biomarkersidentification of new biomarkersinsightknockout genemalignancymarker identificationneoplasm/cancerparalogparalogous genepathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerresistance to Drugresistant to Drugtherapeutic outcometherapy outcometreatment strategytumor cell metabolismtumor metabolism
Description preview
We use our CHyMErA CRISPR screening platform for the mapping of GIs through acute, combinatorial gene perturbation. We designed a GI library targeting genes involved in central metabolism and its regulation, enabling the experimental interrogation for GIs between thousands of gene pairs. We applied this library in human cells cultured in both…
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