grant
Unraveling the systemic manifestations of pulmonary arterial hypertension on lean muscle mass
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025ACRP30 proteinAI systemAcuteAddressAdipose tissueAerobic ActivityAerobic ExerciseAerobic TrainingAerobic fitnessAffectAgonistAppetiteAreaArtificial IntelligenceBicepsBody CompositionCachecticCachexiaCardiac OutputCavitas thoracisCharacteristicsChestChronicClinicClinicalComplexComputer ReasoningCounselingDEXADXADataDesire for foodDiagnosisDietary intakeDietary qualityDual-Energy X-Ray AbsorptiometryDual-Energy Xray AbsorptiometryDysfunctionEducation for InterventionEducational InterventionEnrollmentEvaluationExerciseFailureFatsFatty AcidsFatty ChangeFatty TissueFatty acid glycerol estersFoundationsFunctional disorderGLP-1 receptorGLP-I receptorGastrocnemius MuscleHeartHeart failureHigh PrevalenceHospital AdmissionHospitalizationHybridsImpairmentIndividualInflammationInflammatoryInstruction InterventionIntermediary MetabolismInterventionIntervention TrialInterventional trialIntestinalIntestinesKnowledgeLeadLeannessLeftLow PrevalenceMachine IntelligenceMeasurementMeasuresMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMethodsMorbidityMorbidity - disease rateMuscleMuscle AtrophyMuscle TissueMuscular AtrophyNIR SpectroscopyNear-Infrared SpectrometryNear-Infrared SpectroscopyNutritionO elementO2 elementObesityOrganOutcomeOxygenPathogenesisPathologicPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPhysical activityPhysiologicPhysiologicalPhysiopathologyPilot ProjectsPlayPrognosisProgressive DiseaseProspective cohortProspective, cohort studyPulmonary HypertensionQOLQuality of lifeRadiographyRecommendationReference StandardsResistanceRespiratory MusclesRight Ventricular DysfunctionRight heart dysfunctionRight ventricle dysfunctionRight-sided heart dysfunctionRiskRoentgenographyRoleScanningSkeletal MuscleTechniquesTextureTherapeuticThinnessThoraceThoracicThoracic CavityThoracic cavity structureThoraxTimeTrainingTraining InterventionTransplantationValidationVentilatory MusclesVisceralVoluntary MuscleWeightadipocyte complement-related protein 30-kDaadipocyte, C1q and collagen domain containing proteinadipocytokinesadipokinesadiponectinadiposeadiposityapM-1 proteinapM1 (adipose-specific) proteinbiceps brachii musclebowelcardiac failurechest CTchest computed tomographycohortcorpulencecostcytokinediet qualityendophenotypeenrollexercise capacityexercise interventionfatty acid oxidationgastrocnemiusglucagon-like peptide-1 receptorhealth related quality of lifeheart outputheavy metal Pbheavy metal leadhospitalization rateshypoperfusionimpaired pulmonary vascularizationimprovedindexinginsightinstructional interventioninsulin sensitivitylung vascular diseasemetabolism measurementmetabolomicsmetabonomicsmortalitymuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle strengthmuscle wastingmuscularnovelobese individualsobese peopleobese personobese populationobese subjectspathophysiologypathwaypatient oriented outcomespersonalized health interventionpersonalized interventionphysical activity interventionpilot studyprecision interventionsprospectivepulmonarypulmonary arterial hypertensionpulmonary artery hypertensionpulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vasculopathyradiological imagingresistance exerciseresistance trainingresistantresponseroutine carescreeningscreeningssocial roletransplantvalidationsweightswhite adipose tissueyellow adipose tissue
Description preview
Project Summary
While pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature
associated with high morbidity and mortality, it also has multiple systemic manifestations affecting many
organs. There is a growing body of evidence suggesting respiratory and skeletal muscle dysfunction in patients
with PAH;…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click