grant
Unraveling the Role of Langerhans Cells in Itch
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AcuteAntigensAppearanceAtopic DermatitisAtopic EczemaAtopic NeurodermatitisAutomobile DrivingBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemBurn injuryBurnsCategoriesCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCell-to-Cell InteractionCellsChimeraChimera organismChronicCutaneousCutaneous DisorderCyclic SomatostatinDREADDsDataDendritesDermatosesDevelopmentDisseminated NeurodermatitisEconomic BurdenEpidermisGeneticGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHealth CareHematopoieticImmune systemImmunityImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInflammationIntracellular Communication and SignalingInvestigationItchingKnowledgeLangerhans cellLifeLightLinkMarrow monocyteMediatingMedicalMiceMice MammalsModelingMurineMusNerve EndingsNervous SystemNeurologic Body SystemNeurologic Organ SystemPatientsPhotoradiationPlayPopulationPopulation DynamicsPopulation HeterogeneityPruritic DisorderPruritisPruritusPsoriasisQOLQuality of lifeResearchRoleSRIHSRIH-14ShapesSignal TransductionSignal Transduction SystemsSignalingSkinSkin DiseasesSkin Diseases and ManifestationsSomatostatinSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneSourceSystemic diseaseTechniquesTestingTransgenic MiceVisualizationYolk Sacallergic dermatitisallergic eczemabiological signal transductionburnedcell sortingcell typechimeraschronic itchchronic prurituscutaneous diseasedermal diseasedermal disorderdesigner receptors exclusively activated by designer drugsdevelopmentaldiverse populationsdrivinggrowth hormone release inhibiting factorhemopoieticheterogeneous populationimmunogenitch sensationmonocytemouse modelmurine modeloptogeneticspopulation diversitypsoriasiformpsoriaticrecruitscRNA sequencingscRNA-seqselective expressionselectively expressedself-renewself-renewalsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin disordersocial rolevitelline sac
Description preview
PROJECT SUMMARY
Chronic itch is a considerable medical challenge associated with various skin and systemic diseases, ,
exerting a profound impact on patients' overall quality of life. While the epidermis is conventionally considered
the source of skin itch, critical knowledge gaps persist regarding the role of Langerhans cells (LCs), resident…
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