grant
Unraveling the neural mechanisms for satiety and weight loss by GLP1-based drugs
Organization MONELL CHEMICAL SENSES CENTERLocation PHILADELPHIA, UNITED STATESPosted 5 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AblationAcuteAfferent NeuronsAgonistAlimentary CanalAnatomic SitesAnatomic structuresAnatomyArea PostremaAttenuatedBehavioralBody WeightBody Weight decreasedBrainBrain Nervous SystemCCKCell Communication and SignalingCell NucleusCell SignalingCholecystokininChronicClinicalClinical TrialsComplementComplement ProteinsComplexCranial Nerve XDataDevelopmentDigestive TractDorsalDrug ScreeningDrug Side EffectsDrug TargetingDrugsEatingEncephalonFatsFatty acid glycerol estersFeeding behaviorsFood IntakeFutureGI TractGLP-1GLP-1 receptorGLP-I receptorGastrointestinal TractGastrointestinal tract structureGenerationsGeneticGlp-1High Fat DietHind BrainHypothalamic structureHypothalamusIn Situ HybridizationIndividualIngestive BehaviorIntracellular Communication and SignalingKidneyKidney Urinary SystemLeannessLong-Term EffectsMapsMediatingMedicationMiceMice MammalsMolecularMurineMusNauseaNausea and VomitingNerve CellsNerve UnitNeural CellNeurocyteNeuronsNon-Polyadenylated RNANucleusNutrientObese MiceObesityOutputPancreasPancreaticPancreozyminPathway interactionsPatientsPatternPeripheralPharmaceutical PreparationsPhysiologicPhysiologicalPneumogastric NervePopulationProteinsPublic HealthRNARNA Gene ProductsReceptor ProteinResearchRhombencephalonRibonucleic AcidRoleSatiationSensory NeuronsSignal TransductionSignal Transduction SystemsSignalingStructure of area postremaTechnologyTenth Cranial NerveTestingTherapeuticThinnessUropancreozyminVagus NerveVagus nerve structureViralWeight LossWeight Loss AgentsWeight ReductionWeight-Loss DrugsWorkadiposityalimentary tractattenuateattenuatesbiological signal transductionbody weight lossclinical relevanceclinically relevantcomplementationcorpulencedevelopmentaldiet-associated obesitydiet-induced obesitydiet-related obesitydigestive canaldrug developmentdrug/agenteat lessenergy balanceexperienceexperimentexperimental researchexperimental studyexperimentsfeeding-related behaviorsglucagon-like peptide 1glucagon-like peptide-1 receptorhindbrainhypothalamicin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoin vivo two-photon imagingneuralneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronalnovelnutrient intake activityob/ob mouseobesity interventionobesity therapyobesity treatmentoptogeneticspathwayreceptorreduced eatingreduced food intakerenalresponsesatietyside effectsocial rolesuccesssugarsynaptic circuitsynaptic circuitrytreatment adherencetreatment compliancewt-loss
Description preview
PROJECT SUMMARY
Over the last several decades, obesity rates have been rising, and research has failed to solve this public health
crisis. Now, we are at the precipice of change. Glucagon-like peptide-1 (GLP1)-based obesity drugs have
emerged as a promising strategy for weight loss, and their unprecedented success is transforming the treatment
of…
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