grant
Unraveling the molecular mechanisms of innate immune memory in humans
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2025AddressAdjuvantAffectAfrican ancestryAfrican descentAsian ancestryAsian descentAssayBCG LiveBCG immunizationBCG vaccinationBCG-vaccinatedBacille Calmette-Guerin vaccinatedBacille Calmette-Guerin vaccinationBacille Calmette-GuérinBacillus Calmette GuérinBacillus Calmette-Guerin vaccinationBacillus Calmette-Guérin vaccinationBioassayBiological AssayBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Precursor CellBlood monocyteBone MarrowBone Marrow Reticuloendothelial SystemCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinChromosome MappingCommunicable DiseasesComputational BiologyComputational toolkitControl GroupsCytotoxic cellDataEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEuropean ancestryExpression SignatureGene ExpressionGene Expression ProfileGene LocalizationGene MappingGene Mapping GeneticsGene TranscriptionGene variantGeneticGenetic DiversityGenetic TranscriptionGenetic VariationGenomicsGenotypeGlucansGlucose PolymerHematopoietic Progenitor CellsHematopoietic stem cellsHeterogeneityHumanImmuneImmune memoryImmune responseImmune systemImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic MemoryImmunologicalImmunological MemoryImmunologicallyImmunologicsImmunologyIn VitroIndividualInfectionInfectious DiseasesInfectious DisorderK lymphocyteKnowledgeLinkage MappingLymphoidLymphoid CellM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMTB vaccineMacrophageMapsMarrow NeutrophilMarrow monocyteMeasuresModern ManMolecularMultipotent Stem CellsMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMyelogenousMyeloidMyeloid CellsMyeloid ProgenitorMyeloid Progenitor CellsMyeloid Stem CellsMφNK CellsNatural Killer CellsNatureNeutrophilic GranulocyteNeutrophilic LeukocyteOrganismPBMCPeripheralPeripheral Blood Mononuclear CellPhenotypePlacebosPolyglucosesPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationProgenitor CellsQTLQuantitative Trait LociRNA ExpressionResistanceResolutionSham TreatmentSiteStimulusSubcellular ProcessTB infectionTB vaccineTechniquesTechnologyTestingTotal Human and Non-Human Gene MappingTrainingTranscriptionTransmissionTuberculosisTuberculosis VaccinesVaccinatedVaccinationVaccine for TBVaccine for TuberculosisVaccinesVariantVariationVirulentWorkallelic variantanamnestic reactionanti-TB vaccineblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcell typecomputational toolboxcomputational toolscomputational toolsetcomputer biologycomputerized toolscytokinedisseminated TBdisseminated tuberculosisepigeneticallyfunctional genomicsgene expression patterngene expression signaturegenetic mappinggenetic variantgenome scalegenome-widegenomewidegenomic varianthematopoietic progenitorhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhost responsehuman progenitorhuman stem cellsimmune system responseimmunoresponsein vivoin vivo Modelinfection due to Mycobacterium tuberculosisinnate immune mechanismsinsightinter-individual variabilityinter-individual variationinterdisciplinary approachliving systemlong-term memorylymphocyte precursorlymphocyte progenitorlymphocyte stem celllymphoid precursorlymphoid progenitorslymphoid stem cellmonocytemouse modelmultidisciplinary approachmultipotent progenitormultipotent progenitor cellmurine modelmyeloid precursormyeloid stem and progenitor cellneutrophilpathogenprogenitorrecruitresistantresolutionsresponsescATAC sequencingscATAC-seqsecondary immune responsesecondary infectionsham therapysingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqstem cellstranscriptional profiletranscriptional signaturetransmission processtuberculosis infectiontuberculous spondyloarthropathyvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine candidates against tuberculosisβ-Glucans
Description preview
Innate immune cells have classically been considered to have no immunological memory. However, recent studies have challenged this dogma by demonstrating that innate immune cells, particularly monocytes and macrophages, can mount long-term memory and resistance to reinfection. These observations led to the concept of "trained immunity" - a…
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