grant
Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 16 May 2025Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Absence of pain sensationAbsence of sensibility to painActiqAcuteAcute PainAcutely painfulAddressAdverse effectsAdvisory CommitteesAgitationAnimalsAreaAutonomic nervous systemBindingBronchial ConstrictionBronchial-Dilating AgentsBronchoconstrictionBronchodilationBronchodilator AgentsBronchodilatorsCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCause of DeathCell NucleusCombined Modality TherapyComplementComplement ProteinsCyclicityDataDedicationsDevelopmentDevelopment and ResearchDorsal Motor Nucleus of the VagusDrug ModulationDrugsDuragesicElectrophysiologyElectrophysiology (science)EquilibriumFatal OutcomeFeels no painFentanestFentanylFentylFundingGenerationsGoalsGrantImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIn VitroIndividualInstitutionInterventionInvestigationInvoluntary MuscleK-AwardsK-Series Research Career ProgramsKnowledgeLifeLightMapsMediatingMedicalMedicationMentorshipMethodologyMolecular InteractionMultimodal TherapyMultimodal TreatmentMuscle TonusNaloxoneNarcanNarcantiNerve CellsNerve UnitNetwork AnalysisNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNo sensitivity to painNucleusOperative ProceduresOperative Surgical ProceduresOpiate AntagonistOpiate ReceptorsOpiate receptor antagonistOpiatesOpioidOpioid AntagonistOpioid ReceptorOpioid receptor antagonistOverdosePathway AnalysisPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPeriodicityPharmaceutical AgentPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhentanylPhotoradiationPhysiciansPhysiologyPlayPositionPositioning AttributePsychomotor AgitationPsychomotor ExcitementPsychomotor HyperactivityPsychomotor RestlessnessPublic HealthR & DR&DRegulationResearchResearch Career ProgramRespirationRespiratory DepressionRespiratory physiologyRestlessnessRhythmicityRiskRoleSeveritiesSiteSmooth MuscleSurgicalSurgical InterventionsSurgical ProcedureSystemTask ForcesTechniquesTherapeuticTherapeutic InterventionTrainingUnited StatesVentilatory DepressionVeratridineViralWithdrawalWork of Breathingadvisory teamairway smooth muscleanalgesiaapnea caused by fentanylbalancebalance functioncareercareer developmentcholinergiccombination therapycombined modality treatmentcombined treatmentcomplementationconstrictiondensitydepressed breathingdepression of breathingdetermine efficacydevelopmentaldorsal motor nucleusdrug/agenteffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationelectrophysiologicalevaluate efficacyexamine efficacyexperiencefentanyl evoked respiratory depressionfentanyl induced apneafentanyl induced hypoventilationfentanyl induced respiratory depressionfentanyl induced ventilatory depressionfentanyl mediated respiratory depressionfentanyl respiratory depressionimprovedin vivoin vivo Modelinhibitorinnervationintervention therapylumen dilatormulti-modal therapymulti-modal treatmentmuscle tonenerve supplyneuralneural circuitneural circuitryneural mechanismneural networkneurocircuitryneuromechanismneuronalneuronal circuitneuronal circuitryneurophysiologicalneurophysiologynew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapynucleus ambiguusopiate consumptionopiate crisisopiate drug useopiate intakeopiate overdoseopiate related overdoseopiate therapyopiate useopioid associated apneaopioid associated respiratory depressionopioid consumptionopioid crisisopioid drug overdoseopioid drug useopioid epidemicopioid induced hypoventilationopioid induced overdoseopioid induced respiratory depressionopioid intakeopioid intoxicationopioid mediated respiratory depressionopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid related respiratory depressionopioid respiratory depressionopioid therapyopioid toxicityopioid useopioid ventilatory depressionoptogeneticspatch clamppatient oriented outcomespatient safetypharmaceuticalprofessorprogramsresearch and developmentrespiratoryrespiratory depression caused by fentanylrespiratory depression caused by opioidsrespiratory depression due to opioidsrespiratory functionrespiratory mechanismrespiratory smooth muscleresponsesocial rolesuccesssurgerysynaptic circuitsynaptic circuitrysynthetic opiatesynthetic opioidtherapeutic agent developmenttherapeutic developmenttherapeutically effectivetreatment strategy
Description preview
PROJECT SUMMARY
This career development award will allow Dr. Nicholas Burgraff to establish an independent research career
dedicated to understanding the neurophysiological control of airway function and its intricate
interactions within neural networks that regulate respiration, with a pivotal focus on how various
pharmaceuticals, notably…
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