grant
Unraveling the Impact of Extracellular Vesicle-Loaded FXR1 mRNA on Re-educating Cancer Microenvironment
Organization MEDICAL COLLEGE OF WISCONSINLocation MILWAUKEE, UNITED STATESPosted 11 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY20253q26AddressAmino AcidsAssayAvian Myelocytomatosis Viral Oncogene HomologBand Shift Mobility AssayBandshift Mobility AssayBioassayBiogenesisBiological AssayBladder CancerBreastCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer TreatmentCancersCas nuclease technologyCell BodyCellsCellular ExpansionCellular GrowthCervicalCharacteristicsCheckpoint inhibitorChromosomal dislocationChromosomal translocationChromosomesClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDataDietElectrophoretic Mobility Shift AssayElementsEncapsulatedEndometrialEscalante syndromeExhibitsExtracellular ProteinFMR-1 ProteinFMR1 ProteinFMR1 geneFMRPFMRP proteinFRAXAFemale Reproductive CancerFragile XFragile X Mental Retardation 1 GeneFragile X Mental Retardation ProteinFragile X SyndromeG-QuadruplexG-Quadruplexes DNAG-Quartet StructuresG-QuartetsG-TetradsG4-DNAGene ExpressionGene TranscriptionGenesGeneticGenetic TranscriptionGenetic TranslocationGoalsGynecologic CancerGynecological CancerHead and Neck CancerHead and Neck CarcinomaHomolog of Yeast Vacuolar Protein Sorting 23ImmuneImmune PrecipitationImmune checkpoint inhibitorImmune infiltratesImmune mediated therapyImmunesImmunologically Directed TherapyImmunoprecipitationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapyMYC geneMacrophageMalignant Bladder NeoplasmMalignant CellMalignant Female Reproductive System NeoplasmMalignant Gynecologic NeoplasmMalignant Gynecologic TumorMalignant Head and Neck NeoplasmMalignant MelanomaMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Ovarian NeoplasmMalignant Ovarian TumorMalignant TumorMalignant Tumor of the BladderMalignant Tumor of the Female Reproductive SystemMalignant Tumor of the LungMalignant Tumor of the OvaryMalignant neoplasm of lungMalignant neoplasm of ovaryMalignant neoplasm of urinary bladderMartin-Bell SyndromeMartin-Bell-Renpenning syndromeMediatingMelanomaMental RetardationMessenger RNAMiceMice MammalsMobility Shift AssayMolecular FingerprintingMolecular ProfilingMurineMusMφNamesNon-Polyadenylated RNANucleotidesOncogenesisOncogenicOrigin of LifeOutcomeOvary CancerPD-1 antibodyPD1 antibodyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPhagocytesPhagocytic CellPhenotypePlayProcessProductionProtein BiosynthesisProteinsPublishingPulmonary CancerPulmonary malignant NeoplasmRNARNA ExpressionRNA Gene ProductsRNA-Binding ProteinsRenpenning syndrome 2ReportingResearchResistanceRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleScienceSpecificityStable Isotope LabelingStromal CellsT-CellsT-LymphocyteTSG101TSG101 geneTestingTherapeuticTranscriptTranscriptionTranslation InitiationTranslationsTumor CellTumor PromotionTumor-DerivedTumor-associated macrophagesUpregulationUrinary Bladder CancerUrinary Bladder Malignant TumorVPS23Women's mortalityWorkX-linked mental deficiency-megalotestes syndromeX-linked mental retardation with fragile X syndromeX-linked mental retardation-fragile site 1 syndromeaCTLA-4aCTLA-4 antibodiesaCTLA4aPD-1aPD1amebocyteaminoacidanti programmed cell death 1anti-CTLA-4anti-CTLA-4 antibodiesanti-CTLA4anti-CTLA4 antibodiesanti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 monoclonal antibodiesanti-cancer immunotherapyanti-cancer therapyanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1anticancer immunotherapyautism-fragile X (AFRAX) syndromeautosomebehavior influencebehavioral influencebehavioral plasticityc mycc-myc Genescancer cellcancer immunotherapycancer microenvironmentcancer progressioncancer therapycancer-directed therapycell growthchromosome dislocationchromosome translocationcmyccombinatorialcrosslinkdeath among femalesdeath among womendeath in femalesdeath in womendeath rate among womendeath rate in womendietsexhaustionextracellular vesiclesfemale deathfemale mortalityfra(X) syndromefra(X)(28) syndromefra(X)(q27) syndromefra(X)(q27-28) syndromefragile X FMR1 proteinfragile X mental retardation 1fragile X mental retardation-1 proteinfragile X-mental retardation syndromefragile Xq syndromefragile site mental retardation 1functional plasticitygel shift assaygenetic elementglobal gene expressionglobal transcription profilegynecologic malignancygynecological malignancyhead/neck cancerimmune cell infiltrateimmune check pointimmune check point inhibitorimmune checkpointimmune microenvironmentimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based cancer therapiesimmune-based therapiesimmune-based treatmentsimmunecheckpointimmuno therapyimmunogenicimmunosuppressive activityimmunosuppressive functionimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentimmunotherapy for cancerimmunotherapy of cancerin vivoinnovateinnovationinnovativelung cancermRNAmacro-orchidism-marker X (MOMX) syndromemacro-orchidism-marker X syndromemalignancymalignant head and neck tumormar(X) syndromemarker X syndromemembermental retardation-macroorchidism syndromemolecular profilemolecular signaturemortality among femalesmortality among womenmortality in femalesmortality in womenmyc Oncogenesnamenamednamingneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnovelovarian canceroverexpressoverexpressionpatient oriented outcomesprogramsprotein synthesisresistantsocial rolethymus derived lymphocytetranscriptometranslationtumortumor growthtumor immune microenvironmenttumor microenvironmenttumor progressiontumor susceptibility gene 101tumor-immune system interactionstumorigenesisv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homologvesicle transportvesicular transportwomen's deathwomen's death rateα-CTLA-4α-CTLA4αCTLA-4αCTLA4αPD-1αPD1
Description preview
Abstract
This study focuses on ovarian cancer, a significant cause of mortality among women with gynecological
malignancies. The tumor microenvironment (TME) plays a crucial role in tumorigenesis, and our research
characterize the involvement of fragile X mental retardation autosomal related protein-1 (FXR1), an RNA binding
protein, in ovarian…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click