grant
Unraveling the Aggregation of TDP43 Fragments Associated with ALS and FTD: Insights into Protein Quality Control Mechanisms and Cellular Vulnerability
Organization TEXAS WOMAN'S UNIVERSITYLocation DENTON, UNITED STATESPosted 15 May 2016Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAD dementiaAD related dementiaADRDAPF-1ATP-Dependent Proteolysis Factor 1AffectAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAmyotrophic lateral sclerosis and frontotemporal degenerationAmyotrophic lateral sclerosis and frontotemporal dementiaAssayB cell lymphoma 2B-Cell CLL/Lymphoma 2 GeneB-cell lymphoma/leukemia-2BCL2BCL2 geneBcl-2BioassayBiological AssayBrainBrain Nervous SystemC-terminalCNS Nervous SystemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell AggregationCell BodyCell FunctionCell PhysiologyCell ProcessCell ProtectionCellsCellular FunctionCellular PhysiologyCellular ProcessCentral Nervous SystemCerebrumClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCytoprotectionDefectDegenerative Neurologic DisordersDiseaseDisorderEncephalonEnvironmentFTD dementiaFTD/ALSFTLD/ALSFailureFrontal Temporal DementiaFrontotemporal DementiaFrontotemporal Lobar Degeneration/Amyotrophic lateral sclerosisGehrig's DiseaseGoalsHMG-20High Mobility Protein 20HumanHydrophobicityIntermediary MetabolismKnock-outKnockoutLengthLife ExpectancyLinkLou Gehrig DiseaseMacropainMacroxyproteinaseMetabolic ProcessesMetabolic Protein DegradationMetabolismMiceMice MammalsModern ManMorphologyMotor CellMotor NeuronsMulticatalytic ProteinaseMurineMusNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuraxisNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNormal CellOrganoidsOutcomeParalysis AgitansParkinsonParkinson DiseasePathologicPathway interactionsPersonsPredispositionPrevalencePreventionPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessProsomeProteasomeProteasome Endopeptidase ComplexProtein CleavageProtein FragmentProtein TurnoverProteinsProteolysisProteosomeQuality ControlRegulatory Protein DegradationResearchRiskRoleSiteStressStudentsSubcellular ProcessSusceptibilitySystemTAR DNA-binding protein 43TDP-43TDP-43 aggregateTDP-43 aggregationTDP43TDP43 aggregateTDP43 aggregationTechniquesTexasToxic effectToxicitiesTraumaUbiquitinUniversitiesWomanWorkamyotrophic lateral sclerosis with frontotemporal dementiaamyotrophic lateral sclerosis/FTLDamyotrophic lateral sclerosis/frontotemporal dementiaamyotrophic lateral sclerosis/ftdbcl-2 Genesbrain cellced9 homologcell typecerebralclinical relevanceclinically relevantcostcytoprotectivedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelop therapyfront temporal dementiafrontal lobe dementiafrontotemporal dementia-amyotrophic lateral sclerosisfrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobar dementia amyotrophic lateral sclerosisfrontotemporal lobe degeneration associated with dementiahealth care burdenhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimprovedinduced human pluripotent stem cellsinsightinsoluble aggregateintervention developmentmotoneuronmulticatalytic endopeptidase complexneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationpathwaypressurepreventpreventingprimary degenerative dementiaprotection pathwayprotective pathwayprotein TDP-43protein TDP43protein aggregateprotein aggregationprotein degradationsenile dementia of the Alzheimer typesensorsocial roletherapy developmenttraining opportunitytreatment developmentundergradundergraduateundergraduate student
Description preview
Project Summary
As life expectancy increases, so does the prevalence of Alzheimer’s disease (AD) and AD-related
dementias (ADRD), posing significant healthcare burdens. These conditions are linked to aggregates
of specific proteins or proteolytic fragments in central nervous system cells. For example, C-terminal
fragments (CTFs) of the TAR…
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