grant
Unraveling Neural Circuits for Body Weight Control with Molecular Connectomics
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 1 May 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20263'5'-cyclic ester of AMPACTH-beta-Lipotropin PrecursorAddressAdenosine Cyclic 3',5'-MonophosphateAdenosine Cyclic MonophosphateAdenosine, cyclic 3',5'-(hydrogen phosphate)AffectAfferent NeuronsAnatomic SitesAnatomic structuresAnatomyAppetiteArcuate NucleusAutomobile DrivingAutoregulationBar CodesBiosensorBody WeightBrainBrain Nervous SystemBrain regionC-Fragment EndorphinCachecticCachexiaCalciumCell BodyCell Communication and SignalingCell SignalingCellsCorticotropin-beta-Lipotropin PrecursorCyclic AMPDataDendritesDesire for foodElectrophysiologyElectrophysiology (science)EncephalonEndocrine Gland SecretionEndorphin-ACTH PrecursorEnvironmentFaceFastingFatsFatty acid glycerol estersHigh Fat DietHomeostasisHormonesHumanHypothalamic structureHypothalamusInfundibular NucleusIntermediary MetabolismIntracellular Communication and SignalingLipotropin Fragment CMC3 ReceptorMammaliaMammalsMapsMeasuresMelanocortin 3 ReceptorMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMethodsMiceMice MammalsModern ManMolecularMolecular FingerprintingMolecular ProfilingMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeuropeptidesNeurophysiology / ElectrophysiologyNeurosciencesNuclearObesityPeptidesPhysiological HomeostasisPilot ProjectsPoly APoly(rA)PopulationPro-ACTH-EndorphinPro-Opio-MelanocortinPro-OpiocortinPro-OpiomelanocortinProcessProopiocortinProopiomelanocortinPropertyPublishingRabiesRabies mappingRabies trans synaptic tracingRabies virus mediated mappingReceptor SignalingReceptor, Melanocortin, Type 3ResearchScanning Electron MicroscopySensory NeuronsSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSliceSourceStimulusStructureStructure of nucleus infundibularis hypothalamiSynapsesSynapticTechniquesThesaurismosisVariantVariationWeight maintenance regimenadenosine 3'5' monophosphateadiposityaxon signalingaxon-glial signalingaxonal signalingbarcodebeta-Endorphinbeta-Lipotropin C Fragmentbiological sensorbiological signal transductioncAMPcell typecorpulencedrivingelectrophysiologicalenergy balanceexpression subtypesfacesfacialfastedfastsglia signalingglial signalinghypothalamicin vivoinsightlyssametabolism disordermolecular profilemolecular signaturemolecular sub-typesmolecular subsetsmolecular subtypesmu opioid receptorsnerve signalingneural circuitneural circuitryneural signalingneurochemicalneurochemistryneurocircuitryneuronalneuronal signalingneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetobesity interventionobesity therapyobesity treatmentoptogeneticspatch clamppilot studypolyadenylatepost-synaptic nervespost-synaptic neuronspostsynaptic nervespostsynaptic neuronspresynapticrabies based mappingrabies based retrograde mappingrabies circuit tracingrabies mediated retrograde monosynaptic tracingrabies retrograde tracingrabies tracerrabies tracingrabies viral tracingrabies virus mediated circuit mappingrabies virus monosynaptic circuit tracingrabies virus monosynaptic tracingrabies virus neurotracerrabies virus retrograde tracingrabies virus tracingresponsespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssugarsuperresolution imagingsynapsesynapse functionsynaptic circuitsynaptic circuitrysynaptic functiontracing with rabiestranscriptomicsweight controlweight managementβ-Endorphinμ opioid receptorsμ-ORμOR
Description preview
PROJECT SUMMARY
Identifying synaptically connected neurons is a fundamental challenge in neuroscience, particularly within the
hypothalamus - a brain region that orchestrates energy balance and other homeostatic processes through
intricate and largely unknown neural circuits. Key among these circuits are AgRP (Agouti-related peptide)
neurons and…
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