grant
Unraveling microprotein biology with an evolutionary-immunological framework
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 8 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025Adaptive Immune SystemAmino Acid SequenceAmino AcidsAnimal ModelAnimal Models and Related StudiesAnti-Bacterial AgentsAntigenic DeterminantsAntigensAtlasesAutoantigensAutoimmuneAutoimmune DiseasesAutoimmune ResponsesAutoimmune StatusAutoimmunityAutologous AntigensAutomobile DrivingBinding DeterminantsBiologic ModelsBiologicalBiological ModelsBiologyBody TissuesBrittle Diabetes MellitusCell BodyCell modelCell surfaceCellsCellular ExpansionCellular GrowthCellular modelCodeCoding SystemCognitive DiscriminationDNA mutationDataData AnalysesData AnalysisData SetDevelopmentDisablingDiscriminationEducationEducational aspectsEpitopesEvolutionExhibitsGatekeepingGeneticGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationGenomeGenomicsGoalsHistoryIDDMImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune SurveillanceImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune ToleranceImmune systemImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologic SurveillanceImmunologic ToleranceImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsImmunosurveillanceIndividualInnate Immune ResponseInnate Immune SystemInnate ImmunityInsulin-Dependent Diabetes MellitusJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnock-outKnockoutKnowledgeLiteratureMammaliaMammalsMediatingMiceMice MammalsModel SystemModelingModernizationMolecularMurineMusMutationNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityORFsOpen Reading FramesOrganismPatternPeptidesPhysiologicPhysiologicalPhysiologyPrimary Protein StructureProcessProtein Coding RegionProteinsProteomePublishingRecording of previous eventsResearchRibo-seqRoleSelf-AntigensShapesStructureSudden-Onset Diabetes MellitusT-Cell EpitopesT-CellsT-LymphocyteT-Lymphocyte EpitopesT1 DMT1 diabetesT1DT1DMTechnologyTestingThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissuesTranscriptType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusViralWorkacquired immune systemaminoacidanti-bacterialanti-microbialantimicrobialautoimmune conditionautoimmune disorderautoimmunity diseasebiologiccell growthdark matterdata interpretationdevelopmentaldrivingexperimentexperimental researchexperimental studyexperimentsgain of functiongatekeepergenome annotationgenome mutationgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profilehistoriesimmune healthimmune system functionimmune system healthimmune system toleranceimmune unresponsivenessimmunogenimmunogenicimmunological paralysisinnate immune functioninnovateinnovationinnovativeinsightinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesliving systemloss of functionmodel of animalmouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathogenpressureprotein expressionprotein functionprotein sequenceproteogenomicsribosome footprint profilingribosome profilingsocial rolethymus derived lymphocytetranscriptometranslatometype I diabetestype one diabetes
Description preview
Recent technological advances have revealed the existence of thousands of microproteins (<100 amino acids)
missing from genome annotations, but little is known about their function. The physiological relevance of this
‘biological dark matter’ is one of the biggest outstanding mysteries in modern biology. Compared to canonical
proteins,…
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