grant
Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane Helix
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025AddressAdvisory CommitteesAffectAffinityAmentiaAnesthesiaAnesthesia proceduresAnesthesiologyAnesthestic DrugsAnesthetic AgentsAnesthetic DrugsAnestheticsAwardBindingBinding SitesBiophysicsCharacteristicsCombining SiteComputational TechniqueContracting OpportunitiesContractsCritical CareCryo-electron MicroscopyCryoelectron MicroscopyDataDementiaDevelopmentDevelopment and ResearchDocosahexaenoateDocosahexaenoic AcidsDocosahexenoic AcidsDrug DesignDrugsElectron CryomicroscopyElectrophysiologyElectrophysiology (science)ElementsEquilibriumErwiniaEssential DrugsFamilyFatty AcidsFluorescent ProbesFree EnergyGoalsGrainHumanIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsIonsKnowledgeLigandsLipid BindingLipidsMedicationMedicineMembraneMembrane ChannelsMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMentorsMethodsModelingModern ManModernizationMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular StereochemistryMovementNervous SystemNeural TransmissionNeurologic Body SystemNeurologic Organ SystemNeuromuscular BlockersNeuromuscular Blocking AgentsNeuromuscular DiseasesNeurophysiology / ElectrophysiologyNicotinic Acetylcholine ReceptorsNicotinic ReceptorsOutcomePharmaceutical PreparationsPharmacologyPhosphatidesPhospholipidsPhysiciansPhysiologicPhysiologicalPolyunsaturated Fatty AcidsProteinsPublishingR & DR&DReactive SiteResearchRestScientistSiteStructureSurface ProteinsSynaptic TransmissionSystemTM DomainTask ForcesTechniquesTestingThermodynamicThermodynamicsTransmembrane DomainTransmembrane RegionUniversitiesWashingtonWorkaddictionaddictive disorderadvisory teamalpha-bungarotoxin binding sitesalpha-bungarotoxin receptoralpha7 nicotinic acetylcholine receptoralpha7nAChRbalancebalance functionbiophysical foundationbiophysical principlesbiophysical sciencesbody movementcareercareer developmentchronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentcomputational studiescomputer studiesconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydesensitizationdesigndesigningdevelopmentaldrug developmentdrug discoverydrug/agentelectrophysiologicalenthusiastic atmosphereenthusiastic environmentinnovateinnovationinnovativeinsightinterestlipid boundlipophilicitymembermembrane structuremethod developmentmolecular dynamicsmolecular modelingmyoneural disorderneuroactive steroidsneuromuscular degenerative disorderneuromuscular disorderneurosteroidsnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetprotein functionprotein structureprotein structuresproteins structurerational designresearch and developmentsimulationskillsstructural determinantsstructural factorssupportive atmospheresupportive environmenttreat chronic painα7 nicotinic acetylcholine receptorα7nAChR
Description preview
Project Summary/Abstract
Dr. Mark Arcario is a cardiothoracic anesthesiologist whose long-term goal is to be an independent physician-
scientist studying molecular mechanisms of allostery in ion channels. His research background is in
computational biophysics of membrane proteins with a focus on the effects of lipids and lipophiles on membrane…
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