grant
Unlocking New Chemistries in Extant Enzymes for Synthesizing Bioactive Molecules
NIHUS FederalResearch GrantFY2025AdoptionAminationAminesBioavailabilityBiochemicalBiological AvailabilityBiologyBrainBrain Nervous SystemChemical IndustryChemicalsChemistryClinical Medical SciencesClinical MedicineComplexDMSODemasorbDemesoDimethyl SulfoxideDimethylsulphinylDimethylsulphoxideDirected Molecular EvolutionDomosoDromisolDrug IndustryDrugsElectronsEncephalonEngineeringEnzyme GeneEnzymesExclusionExhibitsFerroprotoporphyrinGrantHealthHemeHeme ProteinsHemeproteinsHumanKnowledgeLaboratoriesLigandsMacromolecular StructureMedicationMedicineMentorsMetalsMethodsModern ManMolecularMolecular StructureNegative Beta ParticleNegatronsNitrogenOrganic SolventsOrganic solvent productOrganismOutcomeOxidantsOxidasesOxidizing AgentsPK/PDPenetrancePharmaceutic IndustryPharmaceutical AgentPharmaceutical IndustryPharmaceutical PreparationsPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhasePhysiologic AvailabilityPrevalencePriceProcessPropertyProtohemeReactionS elementSideSourceSulfoxideSulfurTechnologyTimeToxic effectToxicitiesTransferaseTransferase Geneaminecatalystchemical reactionchemical reaction rateclinical candidatecostdirected evolutiondrug discoverydrug/agentelectron acceptorenzyme activityenzyme mechanismexperienceferrohemefunctional grouphemoproteinimprovedinnovateinnovationinnovativeliving systemmethionine sulfoxide reductasenitreneoxidationpeptide methionine sulfoxide reductasepharmaceuticalpharmacokinetics and pharmacodynamicspricingprospectivereaction ratesuccesstherapeutic candidatethioether
Description preview
Project Summary/Abstract:
Enzymes, supported by their macromolecular structure, can catalyze chemical transformations with exquisite
control, delivering products with high selectivity. The mechanisms that enzymes can support, however, are
limited, making chemical technologies often the preferred method for synthesis, regardless of cost, toxicity,…
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