grant
Unlocking microglia targeting for neurotherapeutics
Organization CHILDREN'S HOSP OF PHILADELPHIALocation PHILADELPHIA, UNITED STATESPosted 20 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AIDS VirusAccelerationAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectAnti-Retroviral AgentsAwardBenchmarkingBest Practice AnalysisBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBrainBrain Nervous SystemCNS Nervous SystemCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCell BodyCell Communication and SignalingCell SignalingCell TherapyCellsCentral Nervous SystemChild CareChildhoodChildren's HospitalChimeraChimera organismClinicalClustered Regularly Interspaced Short Palindromic RepeatsCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCustomDNA TherapyDisturbance in cognitionDrugsEncephalonEngineered GeneEngineeringEnsureFutureGene ExpressionGene Transfer ClinicalGeneralized GrowthGenesGeneticGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic InterventionGenomeGliaGlial CellsGoalsGrowthHIVHSV encephalitisHerpes Simplex EncephalitisHerpes encephalitisHerpetic EncephalitisHortega cellHuman Immunodeficiency VirusesIFNImmuneImmunesImpaired cognitionIn VitroInfectionInjuryInstitutionInterferonsIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKolliker's reticulumLAV-HTLV-IIILentivirinaeLentivirusLibrariesLightLinkLymphadenopathy-Associated VirusMacrophageMediatingMediatorMedicationMedulla SpinalisMentorsMentorshipMethodsMiceMice MammalsMicrogliaMolecularMurineMusMφNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeuraxisNeurocyteNeurogliaNeuroglial CellsNeuroimmuneNeurologicNeurologic DisordersNeurologicalNeurological DisordersNeurologistNeurologyNeuronsNon-neuronal cellNonneuronal cellNucleic AcidsNull MousePathogenesisPathway interactionsPatientsPediatric HospitalsPharmaceutical PreparationsPhiladelphiaPhotoradiationPoint MutationPostdocPostdoctoral FellowPredispositionProductionPuericultureReceptor ProteinRecombinant DNA TechnologyRecombinant adeno-associated virusRecombinant adeno-associated virus (rAAV)RegulationResearchResearch AssociateResearch ResourcesResistanceResourcesRoleSightSignal TransductionSignal Transduction SystemsSignalingSpinal CordStimulator of Interferon GenesStudentsSurvey InstrumentSurveysSusceptibilityTestingTissue GrowthTissuesTrainingTransgenic MiceTransplantationTropismVSVValidationVesicular Stomatitis VirusVesicular stomatitis Indiana virusViralViral ActivityViral DiseasesViral FunctionViral PhysiologyVirus DiseasesVirus-HIVVisionWorkanti-retroviralanti-viral immunityantiviral immunitybenchmarkbiological signal transductionbrain cellcGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychimerasclustered regularly interspaced short palindromic repeats screencognitive dysfunctioncognitive losscustomscyclic GMP-AMP synthase/STINGdesigndesigningdevelop therapydrug/agentfrontiergain of functiongene editing methodgene editing methodologygene editing strategygene editing techniquesgene repair therapygene therapygene-based therapygene-editing approachgenetic therapygenetically engineeredgenomic therapygitter cellglobal gene expressionglobal transcription profileherpes simplex virus 1 encephalitisherpes simplex virus encephalitisin vivoinhibitorinjuriesinsightintervention developmentlentiviral-transducedlentivirally transducedlentivirus transducedleukodystrophymesogliamicroglial cellmicrogliocytemultidisciplinarynerve cementneuroimmunologic diseaseneurological diseaseneuronalnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapyontogenypathwaypediatricperivascular glial cellpost-docpost-doctoralpost-doctoral traineepreservationpreventpreventingprofessorprogramsrAAVreceptorrecombinant AAVresearch associatesresidenceresidential buildingresidential siteresistantresponsescRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapy developmenttooltranscriptometranscriptomicstransduction efficiencytransplanttreatment developmentvalidationsviral infectionvirus infectionvirus-induced diseasevisual function
Description preview
PROJECT SUMMARY/ABSTRACT
Microglia are the long-lived resident macrophages of the brain and spinal cord, which constantly
survey the microenvironment to respond rapidly to injury and infection. Unlike neurons or other
glia, microglia are transplantable, making them ideal candidates for targeted therapies to treat
neurological diseases. A major…
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