grant
University of California and UT Southwestern D-PDTC
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Advanced CancerAdvanced Malignant NeoplasmAffectAsian FemalesAsian WomenAsian ancestryAsian descentAsian groupAsian individualAsian peopleAsian populationAsiansBioinformaticsBiologicalBiological FunctionBiological ProcessCTEPCaliforniaCancer BiologyCancer CenterCancer GenesCancer ModelCancer Therapy Evaluation ProgramCancer-Promoting GeneCancerModelCancersCatchment AreaCause of DeathCell BodyCell Communication and SignalingCell CycleCell Division CycleCell SignalingCellsChromosomal, Gene, or Protein AbnormalityClinicalClinical TrialsCollectionCombination Drug TherapyCombined Modality TherapyComplexComprehensive Cancer CenterCytogenetic or Molecular Genetic AbnormalityDNA mutationDataDecision MakingDevelopmentDigitDigit structureDiseaseDisorderDisparitiesDisparityDrug CombinationsDrugsEGF ReceptorEGFREGFR BlockerEGFR InhibitorEGFR Tyrosine Kinase InhibitorEGFR-TK InhibitorERBB ProteinEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor InhibitorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEpidermal Growth Factor-Urogastrone ReceptorsFDA approvedFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FamilyFrequenciesGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric NeoplasmsGastric Pylorus CancerGastric TumorGeneticGenetic AbnormalityGenetic ChangeGenetic defectGenetic mutationGenomeGenomicsGoalsGrantHER1Health Disparities ResearchHealth disparities related researchImplantIndigenous AmericanIndividuals from minorityIndividuals of minorityInfrastructureIntracellular Communication and SignalingInvestigatorsKinasesLatina PopulationLatina femalesLatina womenLatina/e womenLatina/x womenLatinasLatine femalesLatine womenLatinoLatino PopulationLatino femalesLatino groupLatino individualLatino peopleLatino womenLatinosLatinx femalesLatinx womenLightLos AngelesLung NeoplasmsLung TumorMalignant Gastric NeoplasmMalignant Gastric TumorMalignant NeoplasmsMalignant TumorMalignant Tumor of the LungMalignant neoplasm of lungMechanistic Target of RapamycinMedicationMinorityMinority GroupsMinority PeopleMinority PopulationMinority individualModelingMolecularMolecular AbnormalityMultimodal TherapyMultimodal TreatmentMutateMutationOncogenesOncogenesisPDX modelPI-3K/AKTPI3K/AKTPathway interactionsPatient IsolationPatient derived xenograftPatientsPharmaceutical PreparationsPhosphotransferase GenePhosphotransferasesPhotoradiationPilot ProjectsPolychemotherapyPopulationPopulation HeterogeneityPre-Clinical ModelPre-clinical Drug Testing/DevelopmentPrecision HealthPrecision therapeuticsPreclinical Drug DevelopmentPreclinical Drug Testing/DevelopmentPreclinical ModelsPreclinical TestingProcessProductivityPublishingPulmonary CancerPulmonary NeoplasmsPulmonary malignant NeoplasmR-Series Research ProjectsR01 MechanismR01 ProgramRAFT1RegimenResearchResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ResourcesResearchersResistanceResourcesRisk FactorsRoleSan FranciscoSignal TransductionSignal Transduction SystemsSignalingSiteSmokingSmoking HistorySolidStomachStomach CancerStomach NeoplasmsStomach TumorTGF-alpha ReceptorTestingTexasTimeTransforming GenesTransforming Growth Factor alpha ReceptorTranslatingTransphosphorylasesUnderrepresented Ethnic MinorityUnderrepresented MinorityUniversitiesUrogastrone ReceptorWorkbiologicbiological signal transductionc-erbB-1c-erbB-1 Proteincancer disparitycancer health disparitycancer sub-typescancer subtypescancer-related health disparitycombination chemotherapycombination pharmacotherapycombination therapycombined modality treatmentcombined treatmentcomparativedevelopmentaldiagnosis among femalesdiagnosis among womendiagnosis in femalesdiagnosis in womendiagnosis within femalesdiagnosis within womendisparities in mortalitydisparity in cancerdiverse populationsdrug/agenteffective therapyeffective treatmenterbB-1erbB-1 Proto-Oncogene ProteinerbBlethnic diversityethnic minorityethnically diverseexpectationexpression subtypesfemale diagnosisfemale patientsgastricgastric malignancygenome mutationgroup of colorhealth disparities sciencehealth equityheterogeneous populationindividual of colorindividualized cancer careindividualized oncologylung cancermTORmalignancymalignant stomach neoplasmmalignant stomach tumormammalian target of rapamycinmemberminority patientmolecular aberrationsmolecular sub-typesmolecular subsetsmolecular subtypesmortalitymortality disparitymulti-modal therapymulti-modal treatmentmultidisciplinarymutantneoplasm/cancernever smokernew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpack/yearpathwaypatient derived xenograft modelpatients being femalepatients being womenpatients from minoritypatients of minoritypatients who are femalepeople of colorperson of colorpersonalized oncologypilot studypopulation diversitypopulation of colorpre-clinical drug developmentpre-clinical testingprecision cancer careprecision cancer medicineprecision oncologyprecision therapiesprecision treatmentproto-oncogene protein c-erbB-1racial diversityracial minorityracially diverseresistance mechanismresistantresistant mechanismresponseresponse biomarkerresponse markersresponse to therapyresponse to treatmentsocial rolestomach fundus cancerstomach pylorus cancertargeted cancer therapytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutically effectivetherapy responsetreatment responsetreatment responsivenesstumortumor diagnosistumorigenesisunder-representation of minoritiesunder-represented minorityunderrepresentation of minoritieswomen patientswomen's diagnosis
Description preview
PROJECT SUMMARY/ABSTRACT
The University of California and the University of Texas Southwestern (UCaTS) Diversity Patient-Derived
Xenograft (PDX) Development and Trial Center’s is a diversity-focused grant with a goal of establishing and
characterizing at least 120 new PDXs from racially and ethnically diverse populations and use these PDXs as…
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