grant
Understanding the role of tumor microenvironment in low grade glioma progression to malignancy
Organization CALIFORNIA INSTITUTE OF TECHNOLOGYLocation PASADENA, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025Aberrant ChromosomeAffectArchitectureAssayAtlasesBioassayBiological AssayBody TissuesBrain CancerBrain NeoplasiaBrain NeoplasmsBrain TumorsCNS TumorCNS neoplasmCancersCatalogsCell BodyCell CommunicationCell InteractionCell-to-Cell InteractionCellsCentral Nervous System NeoplasmsCentral Nervous System TumorsChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityChromosomesClassificationClinical stratificationCollaborationsCollectionCommunitiesComputational toolkitCytogenetic AberrationsCytogenetic AbnormalitiesDNADataData SetDeoxyribonucleic AcidDiagnosisEarly DiagnosisEngineering / ArchitectureFreezingGene ExpressionGenesGeneticGlial Cell TumorsGlial NeoplasmGlial TumorGliomaHumanImmuneImmune infiltratesImmunesIndolentInterventionIntervention StrategiesMachine LearningMalignantMalignant - descriptorMalignant Glial NeoplasmMalignant Glial TumorMalignant GliomaMalignant NeoplasmsMalignant Neuroglial NeoplasmMalignant Neuroglial TumorMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainMechanicsMessenger RNAMethodsModelingModern ManMolecularMolecular AnalysisNeuroglial NeoplasmNeuroglial TumorNon-Polyadenylated RNAOutcomePathway interactionsPatientsProcessProteinsProteomicsRNARNA Gene ProductsRecurrenceRecurrentResearchResearch ResourcesResolutionResourcesRibonucleic AcidRisk AssessmentRisk FactorsRoleSamplingSurvival RateSystematicsTechnologyTissue BanksTissue CollectionTissue repositoryTissuesTrainingTranslationsVisualizationWorkbiobankbiorepositorycancer microenvironmentcancer progressioncatalogcell typechromosomal defectchromosome defectclinical riskcohortcomparativecomputational pipelinescomputational toolboxcomputational toolscomputational toolsetcomputerized data processingcomputerized toolsdata modalitiesdata processingearly detectiongenomic datagenomic datasetglial-derived tumorimmune cell infiltrateinteroperabilityintervention designmRNAmachine based learningmachine learning based modelmachine learning modelmalignancymechanicmechanicalmodel buildingmouse modelmulti-modalitymultimodalitymurine modelmutantneoplasm progressionneoplasm/cancerneoplastic progressionneuroglia neoplasmneuroglia tumorneurosurgerynovelpathwayprecancerprecancerouspredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpremalignantpreservationpreventpreventingprospectiveresolutionssocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial integrationspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapeutic targettherapy designtooltranscriptomicstranslationtreatment designtumortumor microenvironmenttumor of the central nervous systemtumor progressiontumors in the braintumors in the central nervous system
Description preview
ABSTRACT. Our PCA research center brings together the UCLA Neurosurgery team with the Caltech spatial single cell team to construct a comparative spatial atlas of low-grade gliomas. The collaboration between the three components of the PCA research center has already generated preliminary data in several glioma samples. We will expand this effort…
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