grant
Understanding the role of mitochondrial specialization in early development
NIHUS FederalResearch GrantFY2025AssayBehaviorBioassayBiological AssayBiologyBiosensorBody TissuesC elegansC. elegansC.elegansCaenorhabditis elegansCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCellsCellular biologyComplexDataDefectDevelopmentDysfunctionElectron TransportEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEpidermisEpitheliumEventFluorescenceFunctional disorderFutureGene TranscriptionGeneticGenetic TranscriptionGenus HippocampusGoalsH+ elementHeterozygoteHumanHydrogen IonsImpairmentIndividualIntestinalIntestinesIntracellular Communication and SignalingMeasuresMediatingMembrane PotentialsMetabolic DiseasesMetabolic DisorderMitochondriaModelingModern ManMorphologyNuclearOrganismOutputOxidative PhosphorylationOxidative Phosphorylation PathwayPhysiopathologyPlayPost-Transcriptional Gene SilencingProcessProductionProtein SubunitsProteinsProtonsRNA ExpressionRNA InterferenceRNA SilencingRNA interference screenRNAiRNAi screenRNAi-based screenRegulationReporterResting PotentialsRoleSeahorseSequence-Specific Posttranscriptional Gene SilencingSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedTestingThesaurismosisTimeTissue DifferentiationTissuesTranscriptionTransmembrane PotentialsVariantVariationWorkbiological sensorbiological signal transductionbowelcell biologycellular differentiationcostdevelopmentaldevelopmental diseasedevelopmental disorderdifferentiation factorselectron transferexperimentexperimental researchexperimental studyexperimentsfluorophoreheterozygosityin vivoinsightliving systemmeetingmeetingsmetabolism disordermitochondrialmitochondrial membranemorphogenic factorsmorphogensnovelpathophysiologyprogramsrespiratorysocial rolespatial temporal imagingspatial temporal mappingspatiotemporal imagingspatiotemporal mappingtool
Description preview
PROJECT SUMMARY
Embryogenesis is an energetically demanding process in which a single cell initiates divisions, giving rise to
progeny that undergo diverse cell fate decisions and complex morphogenetic behaviors to form a multicellular
organism with distinct tissues. Mitochondrial oxidative phosphorylation (OXPHOS) and subsequent ATP
production…
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