grant
Understanding the Role and Regulation of Epithelial Ketogenesis in the Colon
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20262-Propanone3-hydroxy-3-methylglutaryl-CoA3-hydroxy-3-methylglutaryl-coenzyme AAcetoacetatesAcetoneAcidsAddressAffectAnabolismAssayAutoregulationBioassayBiological AssayButyratesCarbonCell CommunicationCell Communication and SignalingCell DifferentiationCell Differentiation processCell InteractionCell SignalingCell-to-Cell InteractionCellular Metabolic ProcessCoACoenzyme AColonDataDimethyl formaldehydeDiseaseDisease remissionDisorderEnergy ExpenditureEnergy MetabolismEnergy-Generating ResourcesEnzyme GeneEnzymesEpithelial CellsEpitheliumFastingGI Stem cellGI microbiotaGastrointestinal microbiotaGenerationsGenus HippocampusGnotobioticGnotobioticsGoalsHDAC AgentHDAC inhibitorHMG-CoAHepaticHistone Deacetylase InhibitorHistone deacetylase inhibitionHomeostasisHost DefenseImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInflammationInjuryIntermediary MetabolismIntervention StrategiesIntestinalIntestinesIntracellular Communication and SignalingIsotopesKetone BodiesKetonesKnowledgeLC/MSLearningMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMicrobeMitochondriaMolecularMurineMusOrganoidsOxidative PhosphorylationOxidative Phosphorylation PathwayPPAR alphaPPAR-αPPARalphaPPARαPathway interactionsPatientsPatternPeroxisome Proliferator-Activated Receptor alphaPeroxisome Proliferator-Activated Receptor αPersonsPhysiological HomeostasisPlayProcessProgenitor CellsProliferatingReceptor ProteinRegulationRemissionResearchResearch TrainingRoleSeahorseShort-Chain Fatty AcidsSignal TransductionSignal Transduction SystemsSignalingSmall IntestinesSourceTechniquesTestingTherapeutic StudiesTherapy ResearchTransgenic MiceVolatile Fatty AcidsWestern BlottingWestern Immunoblottingbasebasesbiological signal transductionbiosynthesisbowelcell metabolismcellular differentiationcellular metabaolismcolon microbescolon microbial communitycolon microbiotacolonic cryptcolonic microbiotacrypt celldefined contributionenergy sourceenteric microbial communityenteric microbiotaepithelial injuryepithelial repairepithelium regenerationfastedfastsgastrointestinal microbial floragastrointestinal stem cellgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloragut progenitorgut stem cellhost microbe associationhost microbe relationshiphost-microbe interactionshost-microbial interactionshost-microorganism interactionshydroxymethylglutaryl-CoAinjuriesinjury and repairinjury responseinterestintestinal cryptintestinal epitheliumintestinal floraintestinal microbiotaintestinal microfloraintestinal progenitorintestinal stem cellsintestinal tract microfloraketogenesisliquid chromatography mass spectrometrymicrobialmicrobial consortiamicrobial floramicrobiotamicrofloramitochondrialmitochondrial dysfunctionmultispecies consortiamutantnovelpathwayprogenitor cell divisionprogenitor cell functionprogenitor cell homeostasisprogenitor cell proliferationprogenitor cell regenerationprogenitor cell renewalprogenitor cell self renewalprogenitor divisionprogenitor functionprogenitor proliferationprogenitor regenerationprogenitor renewalprogenitor self renewalprotein blottingreceptorregenerate epitheliumrepairrepairedresponse to injuryrestorationsmall bowelsocial rolestem and progenitor cell divisionstem and progenitor cell functionstem and progenitor cell proliferationstem and progenitor cell regenerationstem and progenitor cell renewalstem and progenitor cell self renewalstem and progenitor functionstem cell divisionstem cell functionstem cell homeostasisstem cell proliferationstem cell regenerationstem cell renewalstem cell self renewalstem cellstherapeutic targettranslational goaltranslational mission
Description preview
Abstract
Intestinal stem cells (ISCs) play pivotal roles in intestinal epithelium renewal during homeostasis and after injury.
The metabolic demands faced by ISCs require high mitochondrial oxidative phosphorylation (OXPHOS) activity
compared to other differentiated cells. ISCs’ mitochondrial dysfunction has been implicated in the
etiopathogenesis…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click