grant
Understanding the physiology and pathophysiology of kidney-derived vasopressin
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years oldAQP-CDAQP2 proteinAcademic Medical CentersAdultAdult HumanAffectAmino AcidsAntibodiesAntidiuretic HormoneAquaporinsAwardBindingBlood PlasmaBlood PressureBody Weight decreasedBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell Growth in NumberCell MultiplicationCell PolarityCell ProliferationCell SignalingCellsCellular ProliferationChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCommon Rat StrainsCystCyst FluidDataDevelopmentDevelopment PlansDiabetic Kidney DiseaseDiabetic NephropathyDiseaseDisorderDistalDuctDuct (organ) structureDuctal CellDuctal Epithelial CellDysfunctionEducational workshopEncephalonEndocrine Gland SecretionEpithelial Cell ProliferationEquilibriumExtracellular FluidFaculty EducationFaculty TrainingFinancial SupportFluids and SecretionsFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGeneralized GrowthGrowthHealthHormonesHumanHydrogen OxideHypotensionHypothalamic structureHypothalamusIn VitroInstitutionIntracellular Communication and SignalingInvestigatorsKO miceKidneyKidney DiseasesKidney Urinary SystemKnock-out MiceKnockout MiceLow Blood PressureMeasuresMediatingMedical FacultyMedicineMentorshipMiceMice MammalsMitogenesisModelingModern ManMolecular InteractionMurineMusNephrologyNephronsNephropathyNull MousePatientsPhosphorylationPhysiologicPhysiologicalPhysiologyPhysiopathologyPlasmaPlasma SerumPlayPolycystic KidneyPolycystic Kidney DiseasesPopulationPositive Control of Cell ProliferationProductionProliferatingProtein PhosphorylationRatRats MammalsRattusReceptor ActivationReceptor SignalingRegulationRenal DiseaseRenal functionReproducibilityResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRoleSignal TransductionSignal Transduction SystemsSignalingStimulation of Cell ProliferationStimulusStressTeacher EducationTeacher EducatorTeacher PreparationTeacher Professional DevelopmentTeacher TrainingTestingTissue GrowthTransgenic MiceUniversity Medical CentersUriniferous TubeV2 ReceptorsVascular Hypotensive DisorderVasopressinsWCH-CDWaterWater Channel ProteinsWeight LossWeight ReductionWorkWorkshopabsorptionadulthoodaminoacidaquaporin-2aquaporin-CDbalancebalance functionbeta-Hypophaminebiological signal transductionbody weight losscareer developmentcellular polaritychronic kidney diseasecollecting duct water channeldevelopmentalfaculty developmentfaculty professional developmentfinancial aidfinancial assistancehypothalamicinstructor trainingkidney disorderkidney epithelial cellkidney functionmortalitymouse modelmurine modelnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-diabeticnondiabeticnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetontogenypathophysiologypreventpreventingpro-pressophysinpro-vasopressinpropressophysinrenalrenal disordersocial roleteacher developmentwater channelwater transporterwt-loss
Description preview
Chronic Kidney Disease (CKD) affects 15% of the US adult population 30 and vasopressin is
associated with progression of non-diabetic, diabetic, and polycystic kidney disease (PKD). 1-18
However, the specific mechanism(s) through which vasopressin worsens progression of kidney
disease are unclear. Vasopressin is the biologically active end-product…
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