grant
Understanding the origins of the mutational landscape in cancer
Organization UNIV OF ARKANSAS FOR MED SCISLocation LITTLE ROCK, UNITED STATESPosted 24 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026AcidsAddressAdoptedAgingAttentionBody TissuesCancer BiologyCancer InductionCancer ModelCancerModelCancersCell divisionCharacteristicsChronic DiseaseChronic IllnessComplexDNADNA DamageDNA InjuryDNA IntegrationDNA ModificationDNA Modification ProcessDNA analysisDNA lesionDNA mappingDNA mutationDataData SetDeoxyribonucleic AcidDevelopmentDiseaseDisorderEnvironmentEnvironmental ExposureEnvironmental genotoxicantEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFrequenciesFuransGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenome MappingsGenomic DNAGenomicsGenotoxinsHRMSHumanIndividualKnowledgeLarge-Scale SequencingLesionLinkMalignant NeoplasmsMalignant TumorMapsMiceMice MammalsModelingModern ManModificationMurineMusMutagenesisMutagenesis Molecular BiologyMutagensMutationMutation AnalysisNGS MethodNGS systemNucleotidesOncogenesisOutcomePatternPlayPositionPositioning AttributeProbabilityProcessReportingRiskRisk FactorsRoleShapesSingle base substitutionSomatic MutationStable Isotope LabelingTissuesTobacco smokingTobacco smoking behaviorTraininganalyze DNAcarcinogenesischronic disordercomputer based predictiondata diversitydevelopmentaldiverse dataentire genomeenvironmental agentenvironmental mutagenesisenvironmental mutagensepidemiologicepidemiologicalepigeneticallyexposomeexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfull genomefunctional groupgDNAgenome mutationgenome scalegenome-widegenomewidegenotoxic agenthigh resolution mass spechigh resolution mass spectrometryhigh resolution mass spectroscopyhigh rewardhigh riskhigh-resolution mass spectrometerimprovedin vivoinsightlife spanlifespanmalignancymouse modelmurine modelnanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingnovelpredictive modelingrodent genomesingle moleculesocial rolesomatic varianttranslation strategytranslational approachtranslational strategytumortumorigenesiswhole genome
Description preview
PROJECT SUMMARY
Exposure to environmental genotoxins poses a considerable risk, contributing to the formation of pro-mutagenic
DNA lesions. These DNA lesions, in turn, can give rise to mutations and ultimately contribute to the development
of cancer. Unfortunately, our knowledge of the precise origins of subsequent mutations has been hampered by…
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