grant
Understanding the origins of the mutational landscape in cancer
Organization UNIV OF ARKANSAS FOR MED SCISLocation LITTLE ROCK, UNITED STATESPosted 24 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AcidsAddressAdoptedAgingAttentionBody TissuesCancer BiologyCancer InductionCancer ModelCancerModelCancersCell divisionCharacteristicsChronic DiseaseChronic IllnessComplexDNADNA DamageDNA InjuryDNA IntegrationDNA ModificationDNA Modification ProcessDNA analysisDNA lesionDNA mappingDNA mutationDataData SetDeoxyribonucleic AcidDevelopmentDiseaseDisorderEnvironmentEnvironmental ExposureEnvironmental genotoxicantEpidemiologyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFrequenciesFuransGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenome MappingsGenomic DNAGenomicsGenotoxinsHumanIndividualKnowledgeLarge-Scale SequencingLesionLinkMalignant NeoplasmsMalignant TumorMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMiceMice MammalsModelingModern ManModificationMurineMusMutagenesisMutagenesis Molecular BiologyMutagensMutationMutation AnalysisNGS MethodNGS systemNucleotidesOncogenesisOutcomePatternPlayPositionPositioning AttributeProbabilityProcessReportingResolutionRiskRisk FactorsRoleShapesSingle base substitutionSomatic MutationStable Isotope LabelingTissuesTobacco smokingTobacco smoking behaviorTraininganalyze DNAcarcinogenesischronic disordercomputer based predictiondata diversitydevelopmentaldiverse dataentire genomeenvironmental agentenvironmental mutagenesisenvironmental mutagensepidemiologicepidemiologicalepigeneticallyexposomefull genomefunctional groupgDNAgenome mutationgenome scalegenome-widegenomewidegenotoxic agenthigh rewardhigh riskimprovedin vivoinsightlife spanlifespanmalignancymouse modelmurine modelnanopore based sequencingnanopore long read seqnanopore long-read sequencingnanopore seqnanopore sequencingnanopore-based long-read sequencingneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingnovelpredictive modelingresolutionsrodent genomesingle moleculesocial rolesomatic varianttranslation strategytranslational approachtranslational strategytumortumorigenesiswhole genome
Description preview
PROJECT SUMMARY
Exposure to environmental genotoxins poses a considerable risk, contributing to the formation of pro-mutagenic
DNA lesions. These DNA lesions, in turn, can give rise to mutations and ultimately contribute to the development
of cancer. Unfortunately, our knowledge of the precise origins of subsequent mutations has been hampered by…
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