grant
Understanding the OAS/RNase L pathway during pathogenic viral infections
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 15 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAccelerationAnti-viral ResponseAutoimmune DiseasesBiologyBreakbone Fever VirusCOVID-19 virusCOVID19 virusCancer TreatmentCancersCell FunctionCell NucleusCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCoV-2CoV2ComplexCytoplasmCytoplasmic GranulesDENVDENV infectionDengue InfectionDengue VirusDengue fever virusDengue virus infectionDevelopmentDiseaseDisorderGene ExpressionImmuneImmunesImmunomodulationInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AInterferon Type IKnowledgeMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMedicineMessenger RNAMolecularNerve DegenerationNeuron DegenerationNon-Polyadenylated RNANuclearNucleusOrthomyxovirus Type APathogenicityPathway interactionsProcessProductionProtein BiosynthesisRNARNA Gene ProductsRNA NucleasesRNaseRegulationResearchRibonuclease Family ProteinRibonucleasesRibonucleic AcidRibonucleoproteinsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRibosomesSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Subcellular ProcessTranslationsType A InfluenzaViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral GenesViral ProteinsVirusVirus DiseasesWuhan coronavirusanti-cancer therapyautoimmune conditionautoimmune disorderautoimmunity diseasecancer therapycancer-directed therapycoronavirus disease 2019 viruscoronavirus disease-19 virusdengue viral infectiondevelopmentalgene inductiongranulehCoV19immune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinduction of genesmRNAmRNA DecaymRNA ExportmalignancynCoV2neoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationpathogenic viruspathwayprogramsprotein synthesisresponsestress granuletranslationviral infectionviral pathogenvirologyvirus infectionvirus pathogenvirus proteinvirus-induced disease
Description preview
PROJECT SUMMARY
Ribonuclease L (RNase L) is a key component of the mammalian innate antiviral response. For decades, RNase
L was presumed to reduce viral protein synthesis by cleaving ribosomes to arrest translation. However, we and others
recently demonstrated that RNase L-cleaved ribosomes are translation-competent, and that pathogenic viruses…
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