grant
Understanding the mechanisms of maternal antibody interference with oral vaccination
NIHUS FederalResearch GrantFY20260-11 years oldAb-mediated immunityAb-mediated protectionAlimentary CanalAntibodiesAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAttenuatedBiophysicsBlood SampleBlood specimenBreast FeedingBreast MilkBreastmilkCells Placenta-TissueCessation of lifeChildChild YouthChildren (0-21)CirculationClinicalClinical Treatment MoabComplexCord BloodCountryCoupledDataDeathDecidua BasalisDevelopmentDiarrheaDigestive TractDiseaseDisorderDoseEconomic IncomeEconomical IncomeEffector CellEngineeringEnteralEntericEvaluationExclusionFailureFc ReceptorFoundationsFutureGI TractGastroenteritisGastrointestinal TractGastrointestinal tract structureGestationGoalsHumanHuman MilkHuman Mother's MilkHuman poliovirusImmune responseImpairmentIncomeInfantInfectionKO miceKnock-out MiceKnockout MiceKnowledgeLMICLifeMammary Gland MilkMaternal antibodyMaternal placentaMediatingMiceMice MammalsMilkModelingModern ManMolecularMonoclonal AntibodiesMother's MilkMothersMucosal ImmunityMurineMusNeonatalNormal PlacentomaNorthern RhodesiaNull MouseOralOral AdministrationOral Drug AdministrationPlacentaPlacenta Embryonic TissuePlacentomePolio VaccinePolio VirusPoliovirusPoliovirus VaccinesPopulationPredispositionPregnancyReceptor GeneRecombinantsResearchRiskRoleRotavirusRotavirus InfectionsRotavirus VaccinesRouteSalk VaccineSamplingSampling StudiesSusceptibilitySystemTechnologyTestingTimeTransgenic MiceUmbilical Cord BloodVaccinatedVaccinationVaccinesViral DiseasesVirusVirus DiseasesZambiaalimentary tractantibody assayantibody based testantibody receptorantibody testantibody transferantibody-mediated immunityattenuateattenuatesbiobankbiophysical foundationbiophysical principlesbiophysical sciencesbiorepositorycell typecohortcombatdeliver vaccinesdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldigestive canalenteral pathogenenteric pathogenenteropathogenfetal cord bloodhost responseimmune system responseimmunization strategyimmunoresponseincomesinfant infectioninfant morbidityinfant morbidity/mortalityinfected infantinfection rateinsightintestinal pathogenintestine pathogenintraoral drug deliverykidslow and middle-income countriesmAbsmaternal milkmaternal serummonoclonal Absmouse modelmurine modelneonatal immunitynew vaccinesnext generation vaccinesnovelnovel vaccinesoral vaccinephase 3 trialphase III trialplacental transferpoliomyelitis vaccinepoliomyelitis virusprematureprematuritypreventpreventingpuprate of infectionseroconversionsocial rolevaccination strategyvaccine deliveryvaccine developmentvaccine efficacyvaccine responsevaccine responsivenessvaccine strategyvaccine-induced responseviral infectionvirus infectionvirus-induced diseaseyoungster
Description preview
PROJECT SUMMARY
Maternal antibodies (MatAbs) pose a significant challenge to neonatal immune responses, leading to
reduced vaccine efficacy and heightened susceptibility to preventable viral infections. This interference
phenomenon is particularly critical in the context of rotavirus (RV) vaccination, which causes a substantial global
burden of…
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