grant
Understanding the mechanisms behind complement mediated synapse elimination in neuroinflammatory disease
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026AD dementiaAblationAbscissionAddressAdoptedAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAntisense AgentAntisense OligonucleotidesAstrocytesAstrocytusAstrogliaAttenuatedBiologyBody TissuesBrainBrain Nervous SystemC1 qC1qCallithrixCell Communication and SignalingCell SignalingChronicComplementComplement 1qComplement C1qComplement InactivatorsComplement InhibitorsComplement ProteinsDegenerative Neurologic DisordersDemyelinating DiseasesDemyelinating DisordersDemyelinationsDepositDepositionDevelopmentDiminished VisionDiseaseDisease remissionDisorderDisseminated SclerosisEAEEncephalonExcisionExperimental Allergic EncephalitisExperimental Allergic EncephalomyelitisExperimental Autoimmune EncephalitisExperimental Autoimmune EncephalomyelitisExtirpationFISH TechnicFISH TechniqueFISH analysisFISH assayFTD dementiaFluorescence In Situ HybridizationFluorescent in Situ HybridizationFoundationsFrontal Temporal DementiaFrontotemporal DementiaFutureGene variantGliosisGoalsHapaleHealthHortega cellImmunofluorescenceImmunofluorescence ImmunologicImmunofluorescence MicroscopyInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInnate Immune SystemIntracellular Communication and SignalingLateral Geniculate BodyLesionLipopolysaccharidesLow VisionMS patientMarmosetsMediatingMiceMice MammalsMicrogliaMicroscopyModelingMolecular GeneticsMorphologyMultiple SclerosisMurineMusNerve DegenerationNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuron DegenerationPartial SightPatientsPhasePhysiciansPlayPrimary Senile Degenerative DementiaProcessProductionProteinsRNA SeqRNA sequencingRNAseqReduced VisionRelapseRemissionRemovalRetinal Ganglion CellsRodentRodentiaRodents MammalsRoleScientistShort-Tusked MarmosetSignal TransductionSignal Transduction SystemsSignalingSubnormal VisionSurgical RemovalSynapsesSynapticSystemTestingThalamic structureThalamusTherapeuticTherapeutic InterventionTissuesTrainingVisualVisual AcuityVisual impairmentallelic variantantisense oligoastrocytic gliaattenuateattenuatesautoimmune attackautoimmune destructionautoimmune encephalomyelitisautoimmune pathogenesisaxonal degenerationbehavior testbehavioral testbiological signal transductionbrain atrophycareercerebral atrophycohortcomplement systemcomplementationcortical atrophyde-myelinating diseasesde-myelinating disordersdegenerative axondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdensitydevelopmentaleffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsfront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagene complementationgenetic variantgenomic variantgitter cellimmunoneurologyimprovedin vivoinhibitorinsular sclerosisintervention therapyknock-downknockdownlateral geniculatelateral geniculate nucleusmesogliamicroglial cellmicrogliocytemouse modelmultiple sclerosis patientmurine modelneural degenerationneural inflammationneurodegenerationneurodegenerativeneurodegenerative illnessneuroimmunologyneuroinflammationneuroinflammatoryneurological degenerationneurological diseaseneuronal degenerationnew approachesnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionpathogenpatients with MSpatients with multiple sclerosispeople with Multiple sclerosisperivascular glial cellpreservationprimary degenerative dementiaprofound disabilityprogressive neurodegenerationresectionretinal ganglionretinogeniculatescRNA sequencingscRNA-seqsenile dementia of the Alzheimer typeserious disabilitysevere disabilitysingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle moleculesingle-cell RNA sequencingsocial rolesynapsesystemic inflammationsystemic inflammatory responsethalamictherapeutic targettooltraining opportunitytranscriptome sequencingtranscriptomic sequencingtranscriptomicsvision impairmentvisual dysfunctionvisually impaired
Description preview
Project Summary/Abstract
The goal of this proposal is to understand how the complement component C1q impacts multiple
sclerosis (MS)-related neuroinflammatory disease, and to develop a novel strategy to target
complement therapeutically. MS is a neurological disease with an increasing health burden in the US.
Despite significant improvements in…
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