grant

Understanding the interplay of genetic and environmental contributions to human cell fitness

Organization MORGRIDGE INSTITUTE FOR RESEARCH, INC.Location MADISON, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025AddressAreaAssayAutoimmune DiseasesBar CodesBehaviorBioassayBiochemistryBiological AssayBiological ChemistryBiologyBloodBlood CellsBlood PlasmaBlood Reticuloendothelial SystemCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell BodyCell Culture TechniquesCell FunctionCell LineCell PhysiologyCell ProcessCellLineCellsCellular ExpansionCellular FunctionCellular GrowthCellular Metabolic ProcessCellular PhysiologyCellular ProcessCellular biologyCommunicable DiseasesComplexDNADNA Molecular BiologyDataDeoxyribonucleic AcidDependenceDiseaseDisorderEngineeringEnvironmentEnvironmental FactorEnvironmental Risk FactorGene ExpressionGeneticGoalsHumanHuman FigureHuman bodyImmuneImmunesImmunityInfectious DiseasesInfectious DisorderKnowledgeMalignant NeoplasmsMalignant TumorMetabolicModelingModern ManMolecular BiologyNutrientPeripheral Blood CellPhysiologicPhysiologicalPhysiologyPlasmaPlasma SerumProteinsProteomicsReagentResearchReticuloendothelial System, Serum, PlasmaShapesSightStrains Cell LinesSubcellular ProcessSupporting CellSystemT-CellsT-LymphocyteVisionWorkautoimmune conditionautoimmune disorderautoimmunity diseasebarcodebehavior influencebehavioral influencecell behaviorcell biologycell culturecell culturescell growthcell metabolismcellular behaviorcellular metabaolismclustered regularly interspaced short palindromic repeats screencultured cell linedesigndesigningdrug candidatedrug sensitivityenvironmental riskextracellularfitnessgenome editinggenomic editinginnovateinnovationinnovativeinsightmalignancymetabolism measurementmetabolomicsmetabonomicsmultidisciplinaryneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpre-clinicalpreclinicalprogramsthymus derived lymphocytetoolvisual function
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PROJECT SUMMARY
The behavior of all living cells is shaped by a complex and dynamic interplay of intrinsic and extrinsic factors.

However, despite a growing appreciation that metabolic conditions can impact the behavior of human cells, many

key knowledge gaps remain. One major difficulty is that conventional models have several limitations…

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Understanding the interplay of genetic and environmental contributions to human cell fitness — MORGRIDGE INSTITUTE FOR R | Dev Procure