grant
Understanding the causes of second episode cryptococcal meningitis to improve diagnosis and treatment
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 10 Sept 2025Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20255-FC5-FluorocytosineAIDSAIDS VirusAccuracy of DiagnosisAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAdrenal Cortex HormonesAfricaAlcobonAmBAmBisomeAmphocilAmphotecAmphotercin BAmphotericinAmphotericin BAncobonAncotilAnti-Retroviral AgentsAntifungal TherapyAntigensAssayBioassayBiological AssayBrain InflammationC neoformansC. neoformansCell Communication and SignalingCell SignalingCerebrospinal FluidClinicalClinical TrialsColony-forming unitsConcentration measurementConsensusCorticoidsCorticosteroidsCryptococcal MeningitisCryptococcosisCryptococcusCryptococcus neoformansDiagnosisDiagnosticDiagnostic testsDoseDrug ExposureDrugsEarly DiagnosisEarly identificationEncephalitisEquipmentExcess MortalityExposure toFluconazoleFlucytosineFungizoneFutureGenomicsGuidelinesHIVHuman Immunodeficiency VirusesIFN-GammaIFN-gIFN-γIFNGIFNγIL-13IL13Immune InterferonImmune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInfectionInflammatoryInterferon GammaInterferon Type IIInterleukin-13Intracellular Communication and SignalingLAV-HTLV-IIILymphadenopathy-Associated VirusMedicationMeningitisMetabolic Clearance RateMethodologyMinimum Inhibitory Concentration measurementMinimum Inhibitory ConcentrationsMolecular Diagnostic TestingMorbidityMorbidity - disease rateMycologyMysteclin-FOrganismParticipantPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPerformancePersonsPharmaceutical PreparationsPrediction of Response to TherapyPreventative strategyPrevention strategyPreventive strategyProceduresProphylactic treatmentProphylaxisRapid diagnosticsRecurrenceRecurrentRelapseReportingResearchRoleSafetySignal TransductionSignal Transduction SystemsSignalingSterilitySurvivorsSymptomsSyndromeTestingThe science of MycologyTherapeuticTimeTorulaTorulosisToxic effectToxicitiesTreatment FailureUgandaVirus-HIVWorkYeastsaccurate diagnosticsanti-retroviralantigen based testantigen testantiretroviral therapyantiretroviral treatmentbiological signal transductioncerebral spinal fluidclearance rateclinical careclinical decision-makingcohortcostcost effectivecost effectivenessdiagnostic accuracydiflucandrug adherencedrug compliancedrug detectiondrug testingdrug/agentearly detectionequipment acquirementequipment acquisitionequipment investmentequipment procurementequipment purchaseequipment purchasingequipment trainingfluorocytosinefungal infectious disease treatmenthost responsehypoimmunityimmune deficiencyimmune reconstitutionimmune system responseimmunodeficiencyimmunogenimmunoresponseimprovedimproved outcomein vitro testinginfection recurrenceinnovateinnovationinnovativeinstrument acquisitioninstrument investmentinstrument procurementinstrument purchaselFN-Gammaliving systemmanage symptommedication adherencemedication compliancemolecular diagnostic assaysmortalitynovelopen sourcepathogenpatient oriented outcomespharmacologicpredict therapeutic responsepredict therapy responseprospectiverecurrent infectionrecurring infectionside effectsocial rolespinal fluidsterilesymptom managementsystematic reviewtherapy adherencetherapy compliancetherapy failuretherapy predictiontooltreatment predictiontreatment response prediction
Description preview
Abstract
Cryptococcus is the most common cause of HIV-related meningitis with mortality >25%. Symptoms recur in
5–10% of survivors, typically due to either paradoxical immune reconstitution inflammatory syndrome (IRIS)
with sterile cultures or culture-positive relapse of infection. Cerebrospinal fluid (CSF) cryptococcal antigen
(CrAg) testing is…
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