grant
Understanding the association of sleep on monocyte action in HIV infection
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAdhesion MoleculeAdhesionsAffectAfter CareAfter-TreatmentAftercareBasal Transcription FactorBasal transcription factor genesBiologicalBlood monocyteBody TissuesCD14CD14 geneCD16CD16BCPAPCPAP VentilationCardiac DiseasesCardiac DisordersCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCause of DeathCell AdhesionCell Adhesion Molecule GeneCell Adhesion MoleculesCell LocomotionCell MigrationCell MovementCellular AdhesionCellular Immune FunctionCellular MigrationCellular MotilityChronicChronic DiseaseChronic IllnessClinicalComputational BiologyContinuous Positive Airway PressureDevelopmentDevelopment PlansDevelopment and ResearchDrug TherapyDysfunctionElementsEnrollmentEnvironmentEventEvolutionExhibitsExposure toFCGR3BFCGR3B geneFc Receptor III-1Fc gamma IIIb receptorFc-Gamma RIII-BetaFc-Gamma RIIIBFcRIIIBFrequenciesFunctional disorderFutureGene ExpressionGeneral PopulationGeneral PublicGeneral Transcription Factor GeneGeneral Transcription FactorsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHealthHeart DiseasesHeart VascularHourHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHypoxiaHypoxicIgG Fc Receptor IIIBImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunologic DiseasesImmunologic SubtypingImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologyImmunophenotypingIndividualInflammationInflammatoryInflammatory ResponseInterventionKnowledgeLAV-HTLV-IIILow Affinity IgG Fc Receptor IIIBLow Affinity Immunoglobulin Gamma Fc Region Receptor III-BLymphadenopathy-Associated VirusMarrow monocyteMeasuresMedicineMentorshipModelingMolecularMorbidityMorbidity - disease rateObstructive Sleep ApneaOutcomeOxygen DeficiencyPathway interactionsPatientsPersonsPharmacological TreatmentPharmacotherapyPhenotypePhysiciansPhysiopathologyPositionPositioning AttributeProductionProtocolProtocols documentationR & DR&DResearchResearch ResourcesResourcesRiskSamplingScientistSignal PathwaySleepSleep DeprivationSleep DisordersStimulusStressSubgroupSyndrome, Sleep Apnea, ObstructiveSystemTestingTherapeutic InterventionTissuesTrainingTranscription Factor Proto-OncogeneTranscription factor genesUniversitiesUpregulationVirus-HIVWorkantiretroviral therapyantiretroviral treatmentbiologiccardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular riskcardiovascular risk factorcareer developmentcell adhesion proteincell motilitychronic disordercirculatory systemcomputer biologycytokinedeficient sleepdevelopmentaldidactic curriculumdidactic educationdimensional analysisdrug interventiondrug treatmentenrollexperienceexperimentexperimental researchexperimental studyexperimentsheart disorderhigh riskhuman subjectimmune functionimprovedinadequate sleepinsufficient sleepintervention therapymigrationmonocytemortalitynew approachesnovelnovel approachesnovel strategiesnovel strategypathophysiologypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost treatmentprospectiveresearch and developmentresponseresponse to therapyresponse to treatmentscreeningscreeningsskillssleep amountsleep debtsleep deficiencysleep deficitsleep diseasessleep durationsleep dysfunctionsleep episodesleep healthsleep hygienesleep illnesssleep insufficiencysleep intervalsleep lengthsleep losssleep periodsleep problemsleep quantitysleep timesleep wellnesstherapeutic responsetherapy responsetime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingtranscription factortranscriptomicstreatment responsetreatment responsiveness
Description preview
PROJECT SUMMARY/ABSTRACT
As a sleep-medicine physician, I seek to understand how sleep health affects the progression and long-term
consequences of chronic disease and, ultimately, implement sleep-based interventions to improve the health of
patients. Sleep disorders are highly prevalent among people with HIV (PWH), and emerging evidence suggests…
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