grant
Understanding Mechanisms that Regulate Liver Growth and Function
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 1 Jul 2017Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025APAPAcetamidophenolAcetaminophenAcetominophenAddressAlcohol Chemical ClassAlcoholsAntigenic DeterminantsAssayBinding DeterminantsBioassayBiochemicalBiological AssayBloodBlood Reticuloendothelial SystemCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChIP assayChemicalsChromosomal SynapsisChromosome PairingDifferences between sexesDiffers between sexesDrug Metabolic DetoxicationDrug Metabolic DetoxificationDrug PrescribingDrug PrescriptionsERalphaERαESR1ESR1 geneEpitopesEstradiol Receptor alphaEstradiol Receptor αEstrogen Receptor 1Estrogen Receptor alphaEstrogen Receptor αEstrogen ReceptorsExhibitsGeneralized GrowthGenesGenomicsGoalsGrowthHealth Care CostsHealth CostsHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatic lobuleHepatocyteHepatotoxic effectHepatotoxicityHeterogeneityHydroxyacetanilideHyperactivityInjuryInjury to LiverIntermediary MetabolismIntracellular Communication and SignalingKnowledgeLaboratoriesLinkLiverLiver CellsLiver RegenerationLiver ToxicityLiver diseasesLuciferase ImmunologicLuciferasesMediatingMetabolicMetabolic ControlMetabolic Drug DetoxicationsMetabolic PathwayMetabolic ProcessesMetabolismMetabolism of Toxic AgentsMiceMice MammalsMicroscopyModelingMolecularMurineMusNR3A1Natural regenerationNuclear ReceptorsNucleusNutrientParacetamolPathway interactionsPhysiologicPhysiologicalPolyploidPolyploidyPopulationPredispositionProliferatingReceptor ActivationReceptor ProteinRegenerationRegenerative capacityRegenerative responseRegulationResolutionRoleSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSiteStomachSusceptibilitySynapsisTestingTissue GrowthToxic effect on liver cellsTranscriptUnited StatesXenobiotic Metabolismbiological signal transductionchromatin immunoprecipitationchronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disordercombatconstitutive androstane receptorcopingdesigndesigningdetoxificationgastricglobal gene expressionglobal transcription profilehepatic body systemhepatic damagehepatic diseasehepatic injuryhepatic metabolismhepatic organ systemhepatic toxicityhepatopathyhepatoxicityhigh throughput analysishistologic studieshistological studiesinjuriesinjury responseinsightliver damageliver disorderliver functionliver injuryliver metabolismmedication prescriptionmetabolic fitnessnovelnutrient metabolismontogenypathwayprescribed medicationpreventpreventingreceptorreceptor expressionrecruitregenerateregeneration abilityregeneration capacityregeneration potentialregeneration responseregenerative potentialresolutionsresponse to injurysexsex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsocial rolespatial and temporalspatial temporalspatiotemporaltooltoxicanttranscriptometranscriptomics
Description preview
Project Abstract
Chronic liver diseases are on the rise and are associated with almost $100 billion in healthcare
costs in the United States. Since the liver is a primary site for detoxification and metabolizes a
variety of chemicals, prescription drugs, and nutrients, it is prone to constant damage. To cope
with the insults, the liver has…
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