grant
Understanding how SGLT2 inhibitors protect from heart failure
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 May 2026Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202621+ years oldAddressAdultAdult HumanAffectAssayBindingBioassayBiological AssayBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCalorimetryCancersCardiacCardiac BlockCardiac Muscle CellsCardiac MyocytesCardiocyteCas nuclease technologyCausalityCause of DeathCell Culture TechniquesCell RespirationCellular RespirationClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoACoenzyme ACommon Rat StrainsComplexConsumptionCrystallizationDataDeath RateDiabetes MellitusDrugsEnzyme GeneEnzymesEtiologyFeedbackGenerationsGenetics-MutagenesisGenital OrgansGenitaliaGlucose Binding ProteinGlucose Transport ProteinGlucose TransporterHeartHeart BlockHeart Muscle CellsHeart failureHeart myocyteHospital AdmissionHospitalizationHumanHypoglycemiaIn vivo analysisIndividualInfusionInfusion proceduresIntermediary MetabolismIsoformsIsotopesLC/MSLibrariesMalignant NeoplasmsMalignant TumorMedicationMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaModelingModern ManMolecularMolecular InteractionMurineMusMutagenesisMutagenesis Molecular BiologyMyocardialNeurohormonesOutcomePantothenate kinasePantothenic AcidPathologyPathway interactionsPatientsPerfusionPharmaceutical PreparationsPhosphatesPhysiologicPhysiologicalPhysiologyProcessProtein IsoformsRatRats MammalsRattusResearchRodentRodentiaRodents MammalsRoleSGLT 2 inhibitorSGLT2iSodium glucose co-transporter 2 inhibitorStructureTestingThermodynamicThermodynamicsTissuesTitrationsUrinary tract infectionUrinary tract infectious diseaseValidationVitaminsWorkX ray diffractionX ray diffraction analysisXray diffractionadulthoodaerobic metabolismaerobic respirationcandidate identificationcardiac failurecardiac metabolismcardiomyocytecausationcell culturecell culturesdesigndesigningdiabetesdiabetes mellitus therapydiabetes therapydisease causationdrug/agentex vivo perfusionexperienceheart metabolismhypoglycemichypoglycemic episodesimprovedin silicoin vivoin vivo evaluationin vivo testinginfusionsinhibitorinorganic phosphateinterestliquid chromatography mass spectrometrymalignancymitochondrialmortality rateneoplasm/cancerneuroendocrine hormonesneurohormonalnew drug classnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug classnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoxidationoxidative metabolismpantothenatepathwayphase 3 trialphase III trialpreservationprotein structureprotein structuresproteins structurescreeningscreeningsside effectsmall moleculesocial rolestructural biologysuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenturinary infectionvalidations
Description preview
SUMMARY
Heart failure is a leading cause of death worldwide, and the leading cause of hospital admissions in patients
over 65 in the US. The role of metabolism in cardiac pathology has long been of interest, but no therapies that
target cardiac metabolism are known. Recently, Na+/glucose transporter 2 inhibitors (SGLT2i), originally
designed as…
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