grant
Understanding How Nonheme Iron-Dependent Enzymes Assemble Pharmacophores: Studies of Cyclopropane, Aziridine, and Isonitrile Formation
Organization NORTH CAROLINA STATE UNIVERSITY RALEIGHLocation RALEIGH, UNITED STATESPosted 1 Jun 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20251,3-propylenimine2-ketoglutarate2-oxoglutarateAIDS VirusAcidsAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive SitesAddressAdemetionineAdoMetAminesAnabolismAreaAssayAzacyclopropanesAziridinesBindingBioassayBiochemistryBioinformaticsBiological AssayBiological ChemistryBiological MimeticsBiologyBiomimeticsCancersCell SurvivalCell ViabilityChelating AgentsChelatorsChemical StructureChemicalsCluster AnalysesCluster AnalysisCobalaminComparative StudyComplexComplexonsComputer ModelsComputerized ModelsCyclizationDataData BasesDatabasesDecarboxylationDevelopmentDimethyleneiminesDrug TherapyDrugsEngineeringEnzyme GeneEnzyme KineticsEnzymesEpoxidesEpoxy CompoundsEthyleneiminesEthylenimineEthylenimine CompoundFDA approvedFatty AcidsFe elementFe(4+)FlavinsFundingGene ClusterGenomeGenome LibraryGenomic LibraryGenomicsHIVHuman Immunodeficiency VirusesHydrolysisHydroxylasesHydroxylationIndividualInvestigationIronKineticsKnowledgeLAV-HTLV-IIILabelLifeLymphadenopathy-Associated VirusMachine LearningMalignant NeoplasmsMalignant TumorMapsMedicationMetalsMethodsMixed Function OxidasesMixed Function OxygenasesMolecular InteractionMolecular ProbesMononuclearMonooxygenasesMossbauer SpectroscopyMossbauer spectrometryNMR SpectrometerNMR SpectroscopyNatural ProductsNatureNeighborhoodsNuclear Gamma Resonance SpectroscopyO elementO2 elementOpiatesOpioidOrganic SynthesisOutcomeOxygenOxygenasesPathway interactionsPeptidesPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiologic pulsePreparationPrevalenceProcessPropertyProteinsPulsePyridoxal 5-PhosphatePyridoxal PhosphateRationalizationReactionRibosomesRoentgen RaysRoleRouteS elementS-AdenosylhomocysteineS-AdenosylmethionineS-adenosyl methionineS-adenosyl-methionineSAMeSaturated AzacyclopropanesScientistSequence AlignmentSiteSourceStructureSulfurSynthesis ChemistrySynthetic ChemistryTerpene CompoundTerpenesTerpenoidsTestingUncertaintyVanadylVirus-HIVWorkX-RadiationX-Ray RadiationX-rayXrayalpha ketoglutarateamineanalogapplied learningazacyclobutaneazetidinebacteria pathogenbacterial pathogenbio-informatics toolbioinformatics toolbiosynthesiscarbon skeletonchemical functioncofactorcomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingcyclopropanedata basedesigndesigningdevelopmentaldoubtdrug developmentdrug interventiondrug treatmentdrug/agentferryl ionferryl ironfunctional groupgenomic datagenomic datasethalogenationhands-on learningheme ahypertension treatmentinnovateinnovationinnovativeinsightinteractive engagementinteractive learningiron (4+) ioniron(IV)machine based learningmalignancymembermetalloenzymemutation scanningmutation screeningnaturally occurring productneoplasm/cancernovelnuclear magnetic resonance spectroscopypathogenic bacteriapathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacophorepharmacotherapeuticspolyketidespredictive modelingpreparationsprotein structureprotein structure predictionprotein structuresproteins structurescreeningscreeningssecondary metabolitesequencing alignmentsmall moleculesocial rolestereochemistrysynthetic drugtooltraffickingtrimethylenetrimethylenimineα-ketoglutarateα-oxoglutarateαKG
Description preview
Project Summary/Abstract
Late-stage functionalization is a powerful strategy used in nature and in synthetic chemistry to expand structural
complexity and diversity. In natural product biosynthesis, this strategy is exemplified by diverse reactions
catalyzed by metalloenzymes. Among them, non-heme-iron- and 2-oxoglutarate-dependent (Fe/2OG)…
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