grant
Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025BiochemicalBiochemistryBiological ChemistryBiophysicsCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell Surface ReceptorsCell membraneCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyCoupledCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmic MembraneDiseaseDisorderEGF ReceptorEGFRERBB ProteinElectron CryomicroscopyEngineeringEph Family ReceptorsEph Receptor Tyrosine KinaseEph ReceptorsEphrin ReceptorsEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsFamilyHER1IGF1RIGF1R geneIndividualInsulin-Like Growth Factor 1 Receptor GeneIntracellular Communication and SignalingLengthLigand BindingLigandsLinkMembraneMolecularPTK ReceptorsPathway interactionsPlasma MembranePlayProcessReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneSignal TransductionSignal Transduction SystemsSignalingSpecificityStructureSubcellular ProcessTGF-alpha ReceptorTransforming Growth Factor alpha ReceptorTransmembrane Receptor Protein Tyrosine KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUrogastrone Receptorbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesc-erbB-1c-erbB-1 Proteincell biologycryo-EMcryoEMcryogenic electron microscopydesigndesigningdimererbB-1erbB-1 Proto-Oncogene ProteinerbBlerythropoietin-producing human hepatoma receptorextracellularflexibilityflexiblehuman diseasein vivoinsightmembrane structurenovelpathwayplasmalemmaproto-oncogene protein c-erbB-1receptor
Description preview
Abstract
Receptor tyrosine kinases (RTKs) are a large family of single-pass transmembrane cell surface receptors
that play key roles in normal cellular processes and are linked with many human diseases. In general, the
ligand binding to the extracellular region of RTKs induces receptor dimerizaƟon and acƟvaƟon, but many
RTKs cannot be acƟvated…
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