grant
Understanding functions of LTR retrotransposon activation in preimplantation development
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AffectBiologyBlastosphereBody TissuesCRISPR interferenceCRISPR-dCas9-mediated repressionCRISPR/dCas9 interferenceCRISPR/dCas9-mediated transcriptional inhibitionCRISPRiCell BodyCellsChromatinClustered Regularly Interspaced Short Palindromic Repeats interferenceDNA Transposable ElementsDataDevelopmentERVsElementsEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEndogenous RetrovirusesEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvaluationFertilizationFertilization in VitroFertilized EggFertilized OvumGEM modelGEMM modelGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenetically Engineered MouseGenomeGestationGoalsHERVsHumanHuman Endogenous RetrovirusesHuman GenomeKO miceKnock-out MiceKnockout MiceKnowledgeLeu-tRNALong Terminal RepeatsMediatingMethodsMiceMice MammalsModern ManMolecular ConfigurationMolecular ConformationMolecular StereochemistryMorulaMurineMusNull MousePlayPositionPositioning AttributePre-implantation Embryo DevelopmentPre-implantation developmentPregnancyPreimplantation EmbryoPreimplantation Embryo DevelopmentPreimplantation developmentProcessRNA ExpressionRNA HelicaseRegulationRegulatory ElementRepetitive ElementRepetitive RegionsRepetitive SequenceRepressionReproductive MedicineReproductive TechnologyRetrotransposonRoleTest-Tube FertilizationTestingTissuesTotipotencyTotipotentTranscriptionTransposable ElementsWorkbase editingblastocystblastulaconformationconformationalconformational stateconformationallyconformationsdevelopmentalepigeneticallyepigenome profilingepigenomic profilingfertilizationsgene manipulationgenetic manipulationgenetically engineered mouse modelgenetically engineered murine modelgenetically manipulategenetically perturbhuman embryogenesishuman embryonic developmenthuman whole genomeimprovedinsightleucine-tRNAleucyl-tRNAmammalian genomemouse genomemultiomicsmultiple omicsnew approachesnovelnovel approachesnovel strategiesnovel strategynucleic acid long terminal repeatpanomicspre-implantation embryopromoterpromotorpublic health relevancerepressing CRISPR-dCas9 systemsocial rolezygote
Description preview
Understanding the functions of LTR retrotransposon activation in preimplantation development
Abstract
Accumulating evidence indicates that retrotransposons, especially long terminal repeats (LTRs), can act as cis-
regulatory elements, such as promoters and enhancers, to regulate host gene expression. After fertilization, the
mammalian zygote…
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