grant
UNDERSTANDING CADHERIN-11 IN THE DEVELOPMENT AND TREATMENT OF LUNG FIBROSIS
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 10 Feb 2024Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY2025AddressAdhesion MoleculeArchitectureAutoimmuneBehaviorBiologyBleoBleomycinBody TissuesCadherinsCause of DeathCell Adhesion Molecule GeneCell Adhesion MoleculesCell BodyCell surfaceCell-Extracellular MatrixCellsClinicalClinical Treatment MoabComplexCre Lox technologyCre LoxP systemCre lox recombinationCre lox recombination systemCre lox systemCre recombinase/LoxP technologyCre systemDataDepositDepositionDermalDevelopmentDiseaseDisorderECMEngineeringEngineering / ArchitectureEpithelial CellsExposure toExpression SignatureExtracellular MatrixFibroblastsFibrosisFibrotic lesions in lungGene Expression ProfileGene TranscriptionGenetic TranscriptionHeartIn VitroInterstitial Lung DiseasesIntestinalIntestinesLabelLaboratoriesLiposomalLiposomesLiver FibrosisLoxP-flanked alleleLungLung Alveolar EpitheliaLung Respiratory SystemLung Tissue FibrosisLung scarLung tissue scarMacrophageMediatorMiceMice MammalsModelingMolecularMolecular TargetMonoclonal AntibodiesMorbidityMorbidity - disease rateMouse StrainsMurineMusMφNanotechnologyOB-cadherinPathogenesisPathway interactionsPopulationPulmonary FibrosisPulmonary ScarPulmonary Tissue fibrosisRNA ExpressionRegulationRoleSTAT3STAT3 geneScarring at the lungScarring in the lungSclerodermaSystemSystemic SclerodermaSystemic SclerosisTherapeuticTissuesTranscriptionTransgenic Micealveolar epitheliumassess effectivenessbowelcadherin-11cell adhesion proteincutaneous fibrosisdermal fibrosisdermatosclerosisdetermine effectivenessdevelopmentaleffectiveness assessmenteffectiveness evaluationevaluate effectivenessexamine effectivenessfibrogenesisfibrosis in the lungfibrotic liverfibrotic lungfibrotic skinfloxedfloxed allelegene expression patterngene expression signaturehepatic fibrosisin vivoinhibitorinjuredintraperitoneallipid based nanoparticlelipid nanoparticleliposomal deliveryliposome deliverylung developmentlung fibrosismAbsmonoclonal Absmortalitymouse modelmurine modelnano particlenano technano technologynano-sized particlenano-technologicalnanocarriernanoparticlenanosized particlenanotechnanotechnologicalnanovesselnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetosteoblast cadherinpathwaypreventpreventingprogressive systemic sclerosisrecruitscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin fibrosissocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltranscriptional profiletranscriptional signaturetranscriptomicsuptake
Description preview
Project Summary/Abstract. Scleroderma (systemic sclerosis, SSc) is a progressive multisystem, autoimmune
fibrotic disease with a high morbidity and mortality. SSc associated interstitial lung disease is a leading cause
of death. Despite important advances in our understanding of SSc, treatment options remain limited. Identifying
novel therapeutic…
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