grant
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes-Texas Children's Center.
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 5 Mar 2023Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY20260-11 years old19 year old19 years of age9 year old9 years of ageActive Follow-upAddressAdult-Onset Diabetes MellitusAgeAncillary StudyApplication ContextApproaches to preventionBMIBMI percentileBMI z-scoreBehavioralBeta CellBiochemicalBiometricsBiometryBiostatisticsBlackBlack raceBlood PressureBody mass indexCardiovascular DiseasesCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsChildChild YouthChildhoodChildhood diabetesChildren (0-21)Children's HospitalClinicalCollaborationsCommunitiesConsensusContinuous Glucose MonitorCountyCoupledDeteriorationDevelopmentDiabetes MellitusDietDiseaseDisorderDysfunctionEarly identificationEnrollmentEpidemiologyEventFamilyFeedbackFree Fatty AcidsFunctional disorderFundingFutureGenetic MaterialsGeographyGlycohemoglobin AGlycosylated hemoglobin AGoalsHb A1Hb A1a+bHb A1cHbA1HbA1cHealth CareHealth InsuranceHemoglobin A(1)HispanicHormonalIRBIRBsIncidenceInfrastructureInstitutional Review BoardsInsulin CellInsulin ResistanceInsulin Secreting CellIntentionInterventionIntervention StudiesInvestigationInvestigatorsKetosis-Resistant Diabetes MellitusMaturity-Onset Diabetes MellitusMeasuresMediatingMediatorMedical HistoryMedicineMetabolicModelingMulti-center studiesMulticenter StudiesNIDDMNeighborhoodsNon-HispanicNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNonesterified Fatty AcidsNonhispanicNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNot Hispanic or LatinoOGTTObesityObesity EpidemicOnset of illnessOral Glucose Tolerance TestOverweightPathogenesisPediatric HospitalsPersonal Medical HistoryPersonal Medical History EpidemiologyPhasePhenotypePhysical activityPhysiologicPhysiologicalPhysiopathologyPlayPopulationPre-DMPrediabetesPrediabetes syndromePrediabetic StatePrevalencePreventative strategyPrevention approachPrevention strategyPreventive strategyProtocolProtocols documentationPubertyQOLQuality of lifeQuestionnairesQuetelet indexReportingResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk BehaviorsRisk FactorsRisky BehaviorRoleRuralSamplingSedentary behaviorSedentary life-styleSiteSleepSlow-Onset Diabetes MellitusStable Diabetes MellitusStandardizationStressSubcellular ProcessT2 DMT2DT2DMTexasTimeType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesVisitWorkYouthYouth 10-21active followupadiposityadult onset diabetesage 19age 19 yearsage 9age 9 yearsagesat risk behaviorbiobankbiorepositoryblood glucose regulationboyscardiovascular disordercohortcollegecollegiatecontextual factorscontinuous blood glucose monitorcontinuous blood sugar monitorcontinuous glucose measurementcontinuous sugar monitorcorpulencecritical perioddemographicsdesigndesigningdevelopmentaldiabetesdiabetes during childhooddiabetes in childhooddiabetes in childrendiabetes riskdietsdisease onsetdisorder onseteffective therapyeffective treatmentenrollepidemiologicepidemiologicalexperiencefederal poverty levelfollow upfollow-upfollowed upfollowupgirlsglucose controlglucose homeostasisglucose regulationglucose tolerancehealth insurance planhemoglobin A1chigh riskimpaired glucose toleranceimprovedinsulin resistantinsulin sensitivityinsulin toleranceintervention researchinterventional researchinterventional studyinterventions researchketosis resistant diabeteskidsmalleable riskmaturity onset diabetesmodifiable risknine year oldnine years of agenineteen year oldnineteen years oldnovelpathophysiologypediatricpediatric diabetesphase 2 studyphase II studyphenotypic datapre-diabetespre-diabeticprediabeticpreservationpreventpreventingprimary end pointprimary endpointprogression riskpsychologicpsychologicalrecruitresponsescreeningscreeningssecondary end pointsecondary endpointsedentary lifestylesocialsocial roletherapeutic targettimelinetreatment strategytype 2 DMtype II DMtype two diabeteswork groupworking groupyoungsteryouth ageβ-cellβ-cellsβCell
Description preview
Youth-onset type 2 diabetes (YO-T2D) is increasingly prevalent in parallel with the obesity epidemic, yet effective treatment and prevention strategies are limited. The physiologic increase in insulin resistance occurring during puberty, in combination with obesity-related insulin resistance, enhances the risk of T2D. Yet, it remains unclear why…
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