grant
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes - Biostatistics Research Center
Organization GEORGE WASHINGTON UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 1 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldActive Follow-upAddressAdolescentAdolescent YouthAdultAdult HumanAdult-Onset Diabetes MellitusAgreementApproaches to preventionBeta CellBiometricsBiometryBiostatisticsBusiness-Friendly AtmosphereCase Report FormCell FunctionCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessCertificationCharacteristicsChildChild YouthChildhoodChildren (0-21)Chronic stressClinical ResearchClinical StudyClinical TrialsCollaborationsCommunicationComplications of Diabetes MellitusConflict of InterestConsentCoupledCreativenessDataDeteriorationDevelopmentDevicesDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic ComplicationsDifferences between sexesDiffers between sexesDysfunctionEnrollmentEnsureEnvironmental FactorEnvironmental Risk FactorEpidemiologyEthnic OriginEthnicityEventFunctional disorderFundingFutureGenderGenetic MaterialsGoalsHormonalIRBIRBsIncidenceInfrastructureInstitutional Review BoardsInsulin CellInsulin ResistanceInsulin Secreting CellIntentionInterventionInvestigatorsKetosis-Resistant Diabetes MellitusLaboratoriesLeadershipLogisticsManualsManuscriptsMaturity-Onset Diabetes MellitusMediatorMetabolicMethodologyMethodsMonitorMulti-center studiesMulticenter StudiesNIDDKNIDDMNational Institute of Diabetes and Digestive and Kidney DiseasesNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusObesityObesity EpidemicObservation researchObservation studyObservational StudyObservational researchParticipantPathogenesisPerformancePersonsPhenotypePhysiologicPhysiologicalPhysiologyPhysiopathologyPopulation CharacteristicsPrediabetesPrediabetes syndromePrediabetic StatePrevalencePreventative strategyPrevention approachPrevention strategyPreventive strategyPrivatizationProceduresProcessProtocolProtocols documentationPubertyPublicationsQualifyingQuality ControlRaceRacesRandomization trialReportingResearchResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesRiskRisk FactorsSafetyScientific PublicationSedentary behaviorSedentary life-styleSerious Adverse EventSevere Adverse EventSex DifferencesSexual differencesSiteSlow-Onset Diabetes MellitusSpecific qualifier valueSpecifiedStable Diabetes MellitusStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStatistical MethodsStudy TypeSubcellular ProcessSystemT2 DMT2DT2DMTrainingTranslatingType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUniversitiesValidationWashingtonYouthYouth 10-21active followupadiposityadult onset diabetesadulthoodadverse childhood eventsadverse childhood experiencesblood glucose regulationbusiness-friendly environmentclinical research siteclinical sitecohortcollaborative atmospherecollaborative environmentcomparative effectiveness studycorpulencecreativitydata exchangedata managementdata transferdata transmissiondepositorydevelopmentaldiabetesdiabetes controldiabetes mellitus controldiabetes prevention programdiabetes riskeffective therapyeffective treatmentenrollenvironmental riskepidemiologicepidemiologicalethnic diversityethnically diverseexperiencefollow upfollow-upfollowed upfollowupglucose controlglucose homeostasisglucose regulationglycemic controlhigh riskimprovedinnovateinnovationinnovativeinsulin resistantinsulin secretioninsulin sensitivityinsulin toleranceinteractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentjuvenilejuvenile humanketosis resistant diabeteskidsmaturity onset diabetesmeetingmeetingsmultidisciplinarynoveloperationoperationspathophysiologypediatricpeer-group atmospherepeer-group environmentpre-diabetespre-diabeticprediabeticpreservationpreventpreventingprimary outcomeprogramsprogression riskquality assuranceracialracial backgroundracial diversityracial originracially diverserandomized trialrecruitrepositoryresponsesecondary outcomesedentary lifestyleserious adverse experienceserious adverse reactionsex based differencessex-dependent differencessex-related differencessex-specific differencesstatistic methodsstatistical analysisstudy designsuccesstimelinetreatment strategytype 2 DMtype 2 diabetes in childrentype II DMtype two diabetesuser-friendlyvalidationsvirtualweb sitewebsiteyoungsteryouth ageβ-cellβ-cellsβCell
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Youth-onset type 2 diabetes (YO-T2D) is increasingly prevalent in parallel with the obesity epidemic, yet effective treatment and prevention strategies are limited. The physiologic increase in insulin resistance occurring during puberty, in combination with obesity-related insulin resistance, enhances the risk of T2D. Yet, it remains…
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