grant
Understanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral disease
Organization UNIVERSITY OF CALIFORNIA SANTA CRUZLocation SANTA CRUZ, UNITED STATESPosted 1 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY2025ADAMTSARDSAcuteAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAlveolarAlveolar CellApoptosisApoptosis PathwayAutomobile DrivingBody TissuesCOPDCell BodyCell Communication and SignalingCell DeathCell SignalingCellsCellular biologyCessation of lifeChronicChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseCo-cultureCocultivationCocultureCoculture TechniquesDa Nang LungDataDeathDiseaseDisorderDrug TherapyEsteroproteasesFailureFibroblastsFibrosing AlveolitisFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGrippeHospitalsIMiDImmuneImmune infiltratesImmune modulatory therapeuticImmunesImmunologyImpairmentInfectionInflammationInflammation MediatorsInflammatoryInfluenzaInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AIntracellular Communication and SignalingLabelLength of StayLineage TracingLinkLong-Term EffectsLungLung Alveolar EpitheliaLung DiseasesLung InflammationLung ParenchymaLung Respiratory SystemLung TissueLung damageMediatingMediatorModelingMolecularNatureNumber of Days in HospitalOrthomyxovirus Type APathogenesisPathologyPathway interactionsPatientsPeptidasesPeptide HydrolasesPharmacological TreatmentPharmacotherapyPhasePneumonitisPreventionProductionProgrammed Cell DeathProtease GeneProteasesProteinasesProteolytic EnzymesPulmonary DiseasesPulmonary DisorderPulmonary InflammationPulmonary PathologyRecoveryResearchRespiratory Signs and SymptomsRoleSeverity of illnessShock LungSignal TransductionSignal Transduction SystemsSignalingSourceStiff lungStromal CellsStructure of parenchyma of lungSurvivorsSystemTestingTherapeuticTissuesType A InfluenzaViralViral DiseasesViral Respiratory Tract InfectionVirusVirus DiseasesVirus ReplicationWorkacute infectionairway symptomalveolar epitheliumbiological signal transductioncell biologycell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingchronic airway diseasechronic obstructive pulmonary disorderchronic respiratory diseaseclinical relevanceclinically relevantco-morbidco-morbiditycomorbiditydark matterdebilitating symptomdiffuse interstitial pulmonary fibrosisdisease of the lungdisease severitydisorder of the lungdrivingdrug interventiondrug treatmentepithelial progenitorepithelial progenitor cellepithelial repairepithelial stem cellexperienceflow cytophotometryflu infectionflu serotypeflu strainflu subtypeflu viral strainflu virus infectionflu virus strainhealinghigh dimensionalityhospital dayshospital length of stayhospital stayidiopathic pulmonary fibrosisimmune cell infiltrateimmune modulating agentsimmune modulating drugimmune modulating therapeuticsimmune modulatory agentsimmune modulatory drugsimmunomodulating agentsimmunomodulating drugsimmunomodulator agentimmunomodulator drugimmunomodulator medicationimmunomodulator prodrugimmunomodulator therapeuticimmunomodulatory agentsimmunomodulatory drugsimmunomodulatory therapeuticsimmunopathologyimprovedin vivoinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinflammatory mediatorinfluenza infectioninfluenza serotypeinfluenza straininfluenza subtypeinfluenza viral straininfluenza virus infectioninfluenza virus straininhibitorlung disorderlung functionlung injurylung pathologylung repairlung tissue repairmouse modelmurine modelnecrocytosisnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingpulmonary damagepulmonary functionpulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryrepairrepairedrespiratoryrespiratory symptomrestorationsmall moleculesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapeutically effectivetranscriptomicsviral infectionviral multiplicationviral replicationviral respiratory infectionvirus infectionvirus multiplicationvirus-induced diseasewet lung
Description preview
PROJECT SUMMARY
Influenza virus infection triggers lung inflammation and pathology and is a leading cause of acute respiratory
distress syndrome. Following viral clearance, lung inflammation and pathology can persist preventing recovery
from severe cases of infection. Such persistent lung inflammation and pathology, also referred to as Post-viral…
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