grant
Understanding and optimizing antibody-based interventions against neonatal HSV infection
NIHUS FederalResearch GrantFY20250-4 weeks old21+ years old7S Gamma GlobulinAb-mediated immunityAb-mediated protectionAcicloftalAclovirActive Biologic TransportActive Biological TransportActive TransportAcycloguanosineAcyclovirAdultAdult HumanAffinityAntibodiesAntibody TherapyAntibody immunityAntibody protectionAntibody-mediated protectionAutomobile DrivingBehavioralBindingBiologic ModelsBiological ModelsBirthBrain InflammationCNS Nervous SystemCargosilCells Placenta-TissueCentral Nervous SystemCessation of lifeClinicalClinical Treatment MoabCommunicable DiseasesComplexCongenital herpes simplexCongenital herpes simplex infectionCoupledDataDeathDevelopmentDiseaseDisorderEconomic BurdenEncephalitisEpidemiologyEvaluationFc ReceptorFc domainFetal TissuesFetal healthFetusGlycoproteinsGoalsHHV-2HHV2HSVHSV VaccinesHSV infection in neonatesHSV-1HSV-2HSV1HSV2HereditaryHerpes SimplexHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex VirusHerpes Simplex Virus 1Herpes Simplex Virus 2Herpes Simplex Virus Type 1Herpes Simplex Virus Type 2Herpes Simplex Virus VaccinesHerpes labialis VirusHerpes simplex diseaseHerpesviridaeHerpesvirus 1Herpesvirus 2 (alpha), HumanHerpesvirus hominis diseaseHerpesvirus progenitalisHerpesvirusesHumanHuman (alpha) herpes virus 2Human Herpesvirus 2Human herpes simplex virus type 2Humoral ImmunitiesIgGImmune EvasionImmunizationImmunoglobulin GIn VitroInfantInfectionInfectious DiseasesInfectious DisorderInheritedInnate Immune SystemInterventionKnowledgeLifeMaternal antibodyModel SystemModelingModern ManMolecular InteractionMonoclonal AntibodiesMonoclonal Antibody TherapyMorbidityMorbidity - disease rateMothersNeonatalNeonatal MortalityNeonatal herpes simplexNeuraxisNeurologicNeurologicalNewborn InfantNewbornsNormal PlacentomaOutcomeParturitionPathologyPlacentaPlacenta Embryonic TissuePlacentomePlayPopulationPoviralPregnant WomenPreventionRegimenReportingRiskRoleSimplexvirusSimplexvirus VaccinesTestingTherapeuticTherapeutic antibodiesUphill TransportVaccine DesignViralViral BurdenViral DiseasesViral LoadViral Load resultViroraxVirusVirus DiseasesVulnerable PopulationsWorkZoviraxadulthoodaggressive therapyaggressive treatmentantibody based therapiesantibody engineeringantibody receptorantibody transferantibody treatmentantibody-based immunityantibody-based therapeuticsantibody-based treatmentantibody-mediated immunityclinical investigationcongenital herpes simplex virus infectiondeath among neonatesdeath among newbornsdeath in neonatesdeath in newborndesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldrivingepidemiologicepidemiologicalexpectant motherexpectant womenexpecting motherexpecting womenfetalfetal infectionfetus tissueherpes simplex iherpes simplex iiherpes simplex virus 1 infectionherpes simplex virus infectionherpes simplex-1herpes virushuman alphaherpesvirus 2immune evasiveimprovedin vivoindividuals who are pregnantinfection riskinhibiting antibodyinnate immune functioninnovateinnovationinnovativeinsightlife spanlifespanmAB-based therapymAb therapymAb-based therapeuticsmAbsmaternal immune systemmonoclonal Absmortalitymortality among neonatesmortality among newbornsmortality in neonatesmortality in newbornsmother immune systemmouse modelmurine modelneonatal HSV infectionneonatal deathneonatal demiseneonatal healthneonatal herpesneonatal periodneonateneuralnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynew vaccinesnewborn childnewborn childrennewborn deathnewborn healthnewborn mortalitynext generationnext generation therapeuticsnext generation vaccinesnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapynovel vaccinespathogenpeople who are pregnantplacental transferpost-natal periodpostnatal periodpre-clinical studypreclinical studypregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingprophylacticreceptor functionseropositivesocial rolethose who are pregnantvaccine antibodiesvaccine developmentvaccine induced antibodiesvaccine-induced antibodiesviral infectionvirus infectionvirus-induced diseasevulnerable groupvulnerable individualvulnerable peoplewomen who are pregnant
Description preview
ABSTRACT
The fetal/neonatal period represents a unique period of vulnerability to viral infections. While
Herpesviruses such as herpes simplex virus (HSV) are highly prevalent and typically non life-threatening
infections among healthy adults, they are among the most consequential viral infections of early life. HSV
infection during parturition…
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