grant
Understanding A Molecular Cascade That Drives Neutrophil Mediated Pathology In Arthritis
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 9 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025ActinsAddressAdhesionsAffectAllelesAllelomorphsAnti-Bacterial AgentsArthritisAtrophic ArthritisAttenuatedBacteriaBiochemicalBiologyBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood SerumBlood leukocyteBody TissuesCD11bCD62LCD62L AntigensCR3ACRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCausalityCell BodyCell Communication and SignalingCell LineCell LocomotionCell MigrationCell MovementCell SignalingCell surfaceCellLineCellsCellular MatrixCellular MigrationCellular MotilityChemotactic CytokinesChronic DiseaseChronic IllnessCirculationClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollagenCollagen ArthritisCollagen-Induced ArthritisCommunitiesCytoskeletal SystemCytoskeletonDNA Molecular BiologyDataDevelopmentDiarthrosisDiseaseDisease ResistanceDisorderEtiologyEventExhibitsGene TranscriptionGenesGenetic TranscriptionHL-60HL60HLHRCHomologous Chemotactic CytokinesHumanITGAMITGAM geneImmuneImmunesImpairmentInfectious ArthritisInfective ArthritisInflammationInflammatory ArthritisInjectionsIntegrinsIntegrins Extracellular MatrixIntercrinesIntervening SequencesIntracellular Communication and SignalingIntronsJoint DiseasesJointsK/BxNK/BxN modelKBxNKnowledgeL-SelectinLAM-1LAM-1 Leukocyte Adhesion MoleculeLAM-1 geneLECAM-1LECAM1LNHRLSELLYAM-1LYAM1Leu-8 AntigenLeukocytesLeukocytes Reticuloendothelial SystemLungLung Respiratory SystemLymphatic cellLymphocyteLymphocyte Adhesion Molecule 1LymphocyticMAC1AMO1AMarrow NeutrophilMarrow leukocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMel-14 AntigenMiceMice MammalsMinorModelingModern ManMolecularMolecular BiologyMurineMusNeutrophil ActivationNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocytePainPainfulPathogenicityPathologyPatientsPeritoneumPeritonitisPhagocytosisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein ModificationProteinsRNA ExpressionResolutionRheumatoid ArthritisRoleS aureusS. aureusSELL geneSIS cytokinesSelectin L GeneSerumSignal TransductionSignal Transduction SystemsSignalingStaph aureusStaphylococcus aureusStimulusStrains Cell LinesSymptomsSynoviaSynovial FluidSynovial jointSynovitisTQ-1TQ1 AntigenTestingTherapeuticTissuesTranscriptionTransfectionWhite Blood CellsWhite CellZymosananti-bacterialarthriticarthropathicarthropathiesarthropathyattenuateattenuatesbiological signal transductionbonebone erosioncausationcell motilitycell typechemoattractant cytokinechemokinechronic disorderchronic paincultured cell linedevelopmentaldiagnostic tooldisease causationdisease controldisorder controlezrinimprovedin vivoinflamed synovial tissueinflamed synoviuminhibitorinnovateinnovationinnovativeintracellular skeletonjoint disorderlymph cellmembrane-organizing extension spike proteinmicrobialmigrationmoesinmouse modelmurine modelneutrophilnew approachesnew diagnosticsnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation diagnosticsnext generation therapeuticsnovel approachesnovel diagnosticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetpathogenperipheral bloodphosphoprotein p81programsradixinradixin proteinrecruitresistance to diseaseresistant diseaseresistant to diseaseresolutionsresponserheumatic arthritissocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynovial inflammationtherapeutic agent developmenttherapeutic developmenttherapeutic targettoolwhite blood cellwhite blood corpuscle
Description preview
UNDERSTANDING A MOLECULAR CASCADE THAT DRIVES NEUTROPHIL MEDIATED PATHOLOGY IN ARTHRITIS
Rheumatoid arthritis (RA) is a frequent chronic disease of the synovial joints characterized by painful loss
of mobility due to unrestrained inflammation and progressive bone erosion. Disease etiology is poorly
characterized, and the available therapeutic…
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