grant
Uncovering the role of Setbp1 in fibroblast-like synoviocytes during inflammatory arthritis
NIHUS FederalResearch GrantFY2025(TNF)-α21+ years oldAdolescentAdolescent YouthAdultAdult HumanAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptosisApoptosis PathwayArthritisAssayAtrophic ArthritisAutoimmuneAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBinding ProteinsBinding SitesBioassayBiologicalBiological AssayBody TissuesBrainBrain Nervous SystemCRISPRCRISPR/Cas systemCachectinCancersCell BodyCell LineCellLineCellsChIP SequencingChIP-seqChIPseqChronicChronic Childhood ArthritisChronic DiseaseChronic IllnessClassificationClustered Regularly Interspaced Short Palindromic RepeatsCombining SiteComplexDNA BindingDNA Binding InteractionDNA boundDataDefectDevelopmentDiseaseDisease remissionDisorderDown-RegulationDoxycyclineDrug resistanceDrugsDysfunctionEC 2.1.1EVI16Ecotropic Viral Integration Site 16Embryo DevelopmentEmbryogenesisEmbryonic DevelopmentEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFailureFibroblastsFunctional disorderGene ActivationGene Down-RegulationGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic studyGenomic TestingGoalsHDACHDAC ProteinsHematopoieticHeterozygoteHistone DeacetylaseHistonesHomeostasisHumanHyperplasiaHyperplasticImpairmentInflammationInflammatoryInflammatory ArthritisJoint DiseasesJointsJuvenile Chronic ArthritisJuvenile Chronic PolyarthritisJuvenile Rheumatoid ArthritisKidneyKidney Urinary SystemKnock-outKnockoutLigand Binding ProteinLigand Binding Protein GeneLuciferase ImmunologicLuciferasesMacrophage-Derived TNFMalignant NeoplasmsMalignant TumorMedicationMembrana Synovialis Capsulae ArticularisMethyltransferaseMiceMice MammalsModern ManMolecularMolecular AnalysisMolecular InteractionMonocyte-Derived TNFMurineMusMyeloid DiseaseMyeloid MalignancyMyeloid NeoplasmMyeloid TumorMyeloproliferative DisordersMyeloproliferative TumorsMyeloproliferative diseaseNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesOrganPathogenesisPathologicPathologyPatientsPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayProgrammed Cell DeathProliferatingPropertyProtein BindingProteinsPsoriasis ArthropathicaPsoriatic ArthritisRNA SeqRNA sequencingRNAseqReactive SiteRecurrenceRecurrentRegulationRegulatory RegionsRemissionReporterRepressionResearchRheumatoid ArthritisRoleSOX11SOX11 geneSOX4SOX4 geneSRY-Box 11SRY-Box 4SRY-Related HMG-Box Gene 11SRY-Related HMG-Box Gene 4Schinzel-Giedion syndromeShapesSkeletal DevelopmentSpeechStrains Cell LinesSymptomsSynovial MembraneSynovitisSynoviumSystematicsTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTimeTissuesTranscription Factor Proto-OncogeneTranscription RepressionTranscription RepressorTranscription factor genesTranscriptional RepressorTumor Necrosis FactorTumor Necrosis Factor-alphaUpregulationVibramycinWritingadulthoodaging processalpha-6-Deoxyoxytetracyclinearthriticarthropathicarthropathiesarthropathyarticular cartilagebiologicbound proteincartilage degenerationcartilage degradationchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchronic disordercollagen antibody induced arthritiscultured cell linedevelopmentaldrug resistantdrug/agentepigenetic memoryepigeneticallyepigenomicsgain of functiongain of function mutationgene locusgene repressiongenetic locusgenetic regulatory elementgenetic repressorgenome based testinggenome editinggenome testinggenome wide analysisgenome wide studiesgenome-wide analysisgenome-wide identificationgenomic DNA testinggenomic based testinggenomic clinical testinggenomic editinggenomic locationgenomic locusgenomic profiling testinggenomic screening testhealth related quality of lifehemopoieticheterozygosityhistone modificationinflamed synovial tissueinflamed synoviuminsightjoint degenerationjoint degradationjoint destructionjoint disorderjoint tissue degenerationjuvenilejuvenile arthritisjuvenile humanjuvenile idiopathic arthritisloss of functionloss of function mutationmalignancymethylasemouse modelmurine modelmyeloproliferative neoplasmnatural agingneoplasm/cancernormal agingnormative agingpathophysiologypreventpreventingpromoterpromotorrecruitrenalresistance to Drugresistance to therapyresistant to Drugresistant to therapyrheumatic arthritisskeletalskeletogenesissocial rolesubchondral bonesynovial inflammationtherapeutic resistancetherapeutic targettherapy resistanttranscription factortranscriptome sequencingtranscriptomic sequencingtransmethylasetreatment resistance
Description preview
Project Summary
Fibroblast-like synoviocytes (FLS) play a critical role in the pathology of inflammatory joint diseases such as
rheumatoid arthritis, psoriatic arthritis, and juvenile idiopathic arthritis. Under chronic inflammation, FLS undergo
epigenetic remodeling and are transformed into aggressive cancer-like cells, which evade apoptosis,…
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