grant
Uncovering the origin of hypermutability in adult brains
Organization MAYO CLINIC ROCHESTERLocation ROCHESTER, UNITED STATESPosted 15 Nov 2023Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202621+ years oldAD dementiaASDAdultAdult HumanAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAutismAutistic DisorderAutomobile DrivingBloodBlood - brain barrier anatomyBlood CellsBlood Reticuloendothelial SystemBlood-Brain BarrierBrainBrain CancerBrain Nervous SystemBrain regionCancersCardiovascular DiseasesCell BodyCell LineageCell NucleusCell divisionCellsClonal ExpansionClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionConfidence IntervalsDNA amplificationDNA mutationDNMT3aDataDegenerative Neurologic DisordersDevelopmentDiagnosisDiseaseDisorderEarly Infantile AutismEncephalonFoundationsFrequenciesFutureGene variantGenesGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenomeGenomicsGenotypeGerm LinesGilles de la Tourette syndromeGilles de la Tourette's DiseaseGoalsGuinon's diseaseHemato-Encephalic BarrierHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoieticHematopoietic CancerHereditaryHumanIndividualInfantile AutismInfiltrationInheritedJudgmentKanner's SyndromeMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant TumorMalignant Tumor of the BrainMalignant neoplasm of brainModern ManMosaicismMutagenesisMutagenesis Molecular BiologyMutationNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsNucleusPeripheral Blood CellPhenotypePopulationPredispositionPrimary Senile Degenerative DementiaRoleSamplingSchizophreniaSchizophrenic DisordersSingle-Nucleus SequencingSomatic CellSusceptibilityTic Disorder, Combined Vocal and Multiple MotorTourette SyndromeTourette'sTourette's DiseaseTourette's DisorderTourette's SyndromeTransmissionVariantVariationadulthoodage associated diseaseage associated disorderage associated impairmentage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage dependent diseaseage dependent disorderage dependent impairmentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage related human diseaseage related neurodegenerationage-driven neurodegenerative disordersage-related diseaseage-related disorderage-related impairmentage-related neurodegenerative diseaseage-related neurodegenerative disorderagesaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderallelic variantautism spectral disorderautism spectrum disorderautistic spectrum disorderbloodbrain barrierbrain basedcardiovascular disordercell typeclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellscost efficientdeep sequencingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia praecoxdevelopmentaldisease phenotypedrivingentire genomefull genomegenetic variantgenome mutationgenome sequencinggenomic variantgliogenesisglobal gene expressionglobal transcription profilehDNA methyltransferase 3ahematopoietic cell cloneshematopoietic stem cell clonalityhemopoieticmaladie des ticsmalignancymortalitymosaic allelemosaic diseasesmosaic disordersmosaic mutationmosaic variantneoplasm/cancerneuralneurodegenerative illnessneuronalneuropsychiatric diseaseneuropsychiatric disorderprimary degenerative dementiasNuc-Seqschizophrenicsenile dementia of the Alzheimer typesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial roletargeted sequencingtic de Guinontranscriptometransmission processwhole genome
Description preview
Abstract
Genomic variants in an individual may be either inherited (i.e., transmitted through the germline) or
generated by mutagenesis in post-zygotic cells. Widespread genomic mosaicism in somatic cells of
phenotypically normal individuals is now well established. In certain cases, it is known that mutations have
causative role in diseases and…
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