grant
Uncovering Novel Regulatory Pathways and Functions of the Telomerase RNA Component in the Hematopoietic System
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Dec 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20252',3'-exoribonuclease3'-exoribonucleaseAblationAcuteAffectBindingBiogenesisBiologyBloodBlood CellsBlood Precursor CellBlood Reticuloendothelial SystemBone marrow failureCD34CD34 geneCell BodyCell DeathCell SurvivalCell ViabilityCellsCellular StressCellular Stress ResponseCole syndromeCole-Rauschkolb-Toomey syndromeComplementComplement ProteinsComplexCytoplasmDNADNA DamageDNA InjuryDNA analysisDNA mutationDataDeoxyribonucleic AcidDevelopmentDiseaseDisorderDyskeratosis CongenitaEngman syndromeErythroidErythroid CellsFailureGene ExpressionGenesGenetic ChangeGenetic defectGenetic mutationGenomeGoalsHPCA1Hematologic Body SystemHematologic Organ SystemHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic SystemHematopoietic stem cellsHumanHuman EngineeringIn VitroKnowledgeLengthLymphoidLymphoid CellMediatingMiceMice MammalsModelingModern ManMolecularMolecular InteractionMurineMusMutationMyelogenousMyeloidMyeloid CellsNetwork AnalysisNon-Polyadenylated RNAOrigin of LifeOutputPathway AnalysisPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPeripheral Blood CellPhenotypePhysiologicPhysiologicalPositionPositioning AttributeProtocolProtocols documentationQOL improvementRNARNA DecayRNA Gene ProductsRNA ProcessingRNA StabilityRegulationRegulatory PathwayRibonucleic AcidRoleRouteSamplingSeveritiesSystemTelomeraseTelomerase RNA ComponentTelomere MaintenanceTestingTimeTransplantationX-Linked Dyskeratosis CongenitaZinsser syndromeZinsser-Engman-Cole syndromeanalyze DNAblood cell formationblood cell progenitorblood progenitorblood stem cellblood-forming stem cellbone marrow failure syndromecell stresscell typecomplementationcongenital dyskeratosisdevelopmentalexosomeexperimentexperimental researchexperimental studyexperimentsgenome mutationhESChematopoietic differentiationhematopoietic genehematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhuman ES cellhuman ESChuman derived pluripotent stem cellhuman embryonic stem cellhuman pluripotent stem cellhuman progenitorhuman stem cellsimprovements in QOLimprovements in quality of lifein vivomouse modelmurine modelmutantnecrocytosisnovelpathwaypatient oriented outcomespoly A specific exoribonucleasepreventpreventingprogenitor biologyprogenitor cell biologyprogramsquality of life improvementresponsesocial rolestem and progenitor biologystem cell biologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttelomerase RNAtelomeretooltraffickingtransplant
Description preview
PROJECT SUMMARY/ABSTRACT
Mutations in telomerase cause bone marrow failure in patients suffering with dyskeratosis congenita and
other associated telomere biology disorders. While mutations in these patients are found in different components
of telomerase, mutations in genes that regulate the processing of the RNA component of telomerase, TERC,…
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