grant
Ultrasound-induced artificial hibernation: Mimicking natural hibernation to enhance human health
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 5 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AddressAnimalsApoplexyArtificial HibernationAssayBehaviorBioassayBiological AssayBody TemperatureBrainBrain Nervous SystemBrain Vascular AccidentCardiac infarctionCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCommon Rat StrainsComplexCritical PathsCritical PathwaysDNA Molecular BiologyEncephalonEngineeringEvaluationEventFood DeprivationFood deprivation (experimental)Functional ImagingGoalsGrafting ProcedureHealthHibernationHumanHypothalamic structureHypothalamusIncrease lifespanIntermediary MetabolismIon ChannelIonic ChannelsMalignant CellMammaliaMammalsMedicalMedicineMembrane ChannelsMetabolicMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecularMolecular BiologyMurineMusMyocardial InfarctMyocardial InfarctionNerve CellsNerve UnitNervous SystemNeural CellNeural PathwaysNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurosciencesOrgan TransplantationOrgan TransplantsOrgan ViabilityPhysiologicPhysiologic ImagingPhysiologicalPhysiologyProliferatingRatRats MammalsRattusRegulationResearchRoleScienceStrokeSurvival RateSystemTechniquesTechnologyTherapeuticaerospace travelaspirateboost longevitybrain attackcancer cellcardiac infarctcerebral vascular accidentcerebrovascular accidentclinical translationclinically translatablecoronary attackcoronary infarctcoronary infarctiondeprived of fooddisease modeldisorder modelelongating the lifespanenhance longevityextend life spanextend lifespanextend longevityfictionfictional worksfoster longevityheart attackheart infarctheart infarctionhigh rewardhigh riskhypothalamicimprove lifespanimprove longevityinduced hypothermiainnovateinnovationinnovativeinterdisciplinary approachlifespan extensionmultidisciplinary approachneural circuitneural circuitryneural controlneural regulationneurocircuitryneuromodulationneuromodulatoryneuronalneuroregulationnon-human primatenonhuman primateorgan allograftorgan graftorgan xenograftphysiological imagingprogramsprolong lifespanprolong longevitypromote lifespanpromote longevitysocial rolespace travelstroke modelstroke therapystroke treatmentstrokedstrokessupport longevitysynaptic circuitsynaptic circuitrytraittreating strokeultrasound
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Project Summary/Abstract
Hibernation is one of the most remarkable physiological traits observed across a spectrum of animal species.
Hibernating mammals reside primarily in a state known as torpor, characterized by lowered metabolism and
reduced body temperature to conserve energy and survive harsh conditions. This natural phenomenon has
inspired…
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