grant
Ultrafast optical brain imaging via blurred matrix completion
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20252-photon2-photon microscopy3-D structure3-dimensional structure3D structureAlgorithmsAnimal ModelAnimal Models and Related StudiesAreaArtifactsBiochemicalBiologicalBiophysicsBody TissuesBrachydanio rerioBrainBrain Nervous SystemBrain imagingCalciumCell Communication and SignalingCell SignalingCommunitiesComplexDanio rerioDataDevelopmentDimensionsDopamineDysfunctionEncephalonEngineeringFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyFunctional disorderFutureGlutamatesHydroxytyramineImageImaging ProceduresImaging TechnicsImaging TechniquesImaging technologyIntracellular Communication and SignalingKnowledgeL-GlutamateLabelLarvaLightLinkMeasurementMechanicsMethodsMiceMice MammalsMicroscopeMicroscopyModelingModificationMolecularMorphologic artifactsMotionMsecMurineMusNeuronal DysfunctionNeurophysiology - biologic functionNeurosciencesOpticsOrganPhotic StimulationPhotoradiationPhysiopathologyRandom AllocationRandom SelectionRecoveryResearch ResourcesResolutionResourcesSamplingScanningShapesSignal TransductionSignal Transduction SystemsSignalingSpeedSumSystemTechniquesTechnologyTestingTimeTissuesTransgenic MiceVideo MicroscopyVideomicrographyVideomicroscopyVisual StimulationZebra DanioZebra FishZebrafishbiologicbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesbrain circuitrybrain visualizationbrain volumecell typedesigndesigningdevelopmentalfluorescence imagingfluorescent imagingglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalingimage-based methodimagerimagingimaging approachimaging based approachimaging capabilitiesimaging in miceimaging methodimaging modalityimaging studies for miceimaging studies in miceimprovedin vivointerestlenslensesmechanicmechanicalmice imagingmillisecondmodel of animalmulti-photonmurine imagingneuralneural dysfunctionneural functionnew technologynext generationnovelnovel technologiesoptic imagingopticaloptical imagingoptical sensorpathophysiologyreconstructionresolutionssensorsimulationspatial and temporalspatial temporalspatiotemporaltemporal measurementtemporal resolutionthree dimensional structuretime measurementtwo photon excitation microscopytwo photon microscopytwo-photonvoltage
Description preview
Summary: Neural computation is a global phenomenon driven by a myriad of local, granular
biophysical phenomena at millisecond time-scales. Advancing our knowledge of neural function
and dysfunction requires new technologies that can capture granular information over large areas
at fast framerates. We propose a new computational imaging approach…
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