grant
UAB CFRC Core B: Animal and Preclinical Models Core
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Apr 2007Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AccelerationAlimentary CanalAnimal ModelAnimal Models and Related StudiesAnimalsAreaAssayBioassayBiological AssayBiomedical ResearchBody TissuesBreedingBronchoscopyCAT scanCF miceCF mouse modelCF patientsCFTRCFTR ProteinCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCT X RayCT XrayCT imagingCT scanCas nuclease technologyCellular biologyCharacteristicsChronicCiliaClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCommon Rat StrainsCommunitiesComplementComplement ProteinsComputed TomographyCost SavingsCoughingCrossbreedingCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDNA mutationDefectDigestive TractDiseaseDisorderDoppler OCTDrug DeliveryDrug Delivery SystemsDrug MonitoringDysfunctionENaCElectrophysiologyElectrophysiology (science)End Point AssayEndocrine systemEndocrine/Metabolic Organ SystemEndpoint AssaysEpithelial PhysiologyEpitheliumEquipmentFamily suidaeFerretsFosteringFunctional disorderGI TractGastrointestinal TractGastrointestinal tract structureGene TargetingGenerationsGenesGeneticGenetic ChangeGenetic HeterogeneityGenetic HybridizationGenetic defectGenetic mutationGenomeGenotypeGlucose IntoleranceGoalsHormonal SystemImageInternationalInvestigatorsKnock-outKnockoutLaboratoriesLungLung Respiratory SystemMeasurementMeasuresMediatingMetabolic/Endocrine Body SystemMiceMice MammalsModelingMonitorMouse StrainsMucociliary ClearanceMucociliary TransportMucoviscidosisMurineMusMutationNasalNasal Passages NoseNeurophysiology / ElectrophysiologyNoseOCT TomographyObstructionOptical Coherence TomographyOutcome MeasureP. aeruginosa infectionPancreasPancreaticPathogenesisPathway interactionsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePhysiologicPhysiologicalPhysiopathologyPigsPlayPlethysmographyPre-Clinical ModelPreclinical ModelsPredispositionPropertyPseudomonas aeruginosa infectionPublicationsPulmonary Body SystemPulmonary Organ SystemRatRats MammalsRattusRecombinantsResearchResearch PersonnelResearch PriorityResearch ResourcesResearch SupportResearchersResource SharingResourcesRespiratory SystemRespiratory System, Nose, Nasal PassagesRespiratory TractsRespiratory tract structureRoleSample SizeScientific PublicationSpecimen HandlingSpecimen ProcessingStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationSuidaeSusceptibilitySwineTAL effector nucleaseTAL endonucleaseTALE nucleaseTALEN technologyTALENsTechnical ExpertiseTechniquesTechnologyTissue SampleTissuesTomodensitometryTransgenic OrganismsTranslationsX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyX-ray microtomographyXray CAT scanXray Computed TomographyXray computerized tomographyXray microtomographyalimentary tractassess effectivenesscatscancell biologyclinical predictorsclinical relevanceclinical translationclinically relevantclinically translatablecomplementationcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographycystic fibrosis mousecystic fibrosis mouse modelcystic fibrosis patientscystic fibrosis transmembrane regulatordetermine effectivenessdigestive canaleffectiveness assessmenteffectiveness evaluationelectrophysiologicalendocrine gland/systemepithelial Na+ channelepithelial sodium channelevaluate effectivenessexamine effectivenessgene editing methodgene editing methodologygene editing strategygene editing techniquesgene manipulationgene-editing approachgenetic manipulationgenetically manipulategenetically perturbgenital tractgenome mutationhuman diseaseimage-based methodimagingimaging methodimaging modalityin vivoindividuals with CFindividuals with cystic fibrosisinfected with P. aeruginosainfected with Pseudomonas aeruginosainnovateinnovationinnovativeinterestlung functionmRNA Decaymeasurable outcomemicro CTmicro computed tomographymicroCTmicrotomographymodel of animalmouse modelmucus clearancemurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-contrast CTnoncontrast CTnoncontrast computed tomographynovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoptical Doppler tomographyoptical coherence Doppler tomographyoutcome measurementpathophysiologypathwaypatients with CFpatients with cystic fibrosispharmaceuticalpig modelpiglet modelporcineporcine modelpre-clinicalpreclinicalpromoterpromotorpulmonary functionreproductive tractresponse to therapyresponse to treatmentsocial rolestatistical analysissuidsuper high resolutionsuperresolutionswine modeltechnical skillstherapeutic responsetherapy responsetooltranscription activator-like effector nucleasestransgenictranslationtreatment responsetreatment responsivenessultra high resolutionultrasound
Description preview
Project Summary/Abstract
Animal models have become an increasingly valuable tool for biomedical research. Animal models are
particularly relevant to the understanding of cystic fibrosis (CF), where they are used extensively to
characterize CFTR expression and function and investigate the pathophysiology of cystic fibrosis. Furthermore,
animal…
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