grant
Type 2 Inflammation and Remodeling Elicited Through an LTE4/OXGR1-dependent pathway
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Feb 2018Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AcetylcholineAllergensAllergic inflammationAssayAutomobile DrivingBasal CellBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBleoBleomycinBody TissuesCell BodyCell DifferentiationCell Differentiation processCellsChronicCys-LTDREADDsDataDevelopmentDistalElementsEpithelial CellsEpitheliumFISH TechnicFISH TechniqueFISH analysisFISH assayFilamentous FungiFluorescence In Situ HybridizationFluorescent in Situ HybridizationGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGlandGoalsGoblet CellsGrantGrippeHelminthsHistologicHistologicallyHost DefenseHouse Dust MitesHousedust MitesHumanIL-13IL13ImmuneImmune systemImmunesInflammationInflammatoryInfluenzaInterleukin-13IntestinalIntestinesLTE4LabelLeukotriene E-4Leukotriene E4Local TherapyLocalized TherapyLungLung Respiratory SystemLung damageLymphoid CellMesenchymalMetaplasiaMetaplastic ChangeMiceMice MammalsModern ManMoldsMolecularMucosaMucosal TissueMucous MembraneMultiple PolypsMurineMusNasalNasal Passages NoseNoseParasitic WormsPathologicPathway interactionsPatientsPatternPlayPopulationPyroglyphidaeRNA SeqRNA sequencingRNAseqReceptor ProteinRegenerative pathwayReporterReportingRespiratory EpitheliumRespiratory System, Nose, Nasal PassagesRoleSensorySentinelShapesSpecialized Epithelial CellStructure of respiratory epitheliumSubmucosaSurfaceTaste BudsTestingTissuesTracheaTrachea ProperTracheal EpitheliumTranscription Factor Proto-OncogeneTranscription factor genesWound Repairaeroallergensairborn allergenairborne allergenairway epithelial stem cellsairway epitheliumairway epithelium inflammationairway inflammationairway injuryairway progenitorairway remodelingairway repairairway stem cellsbowelcellular differentiationchronic inflammatory diseasechronic rhinosinusitiscysteinyl-leukotrienecytokinedesigner receptors exclusively activated by designer drugsdevelopmentaldrivingepithelium regenerationimpaired airwayinjured airwaylipid mediatorlung functionlung injurylung repairlung tissue repairmicrobial consortiamicrobial floramicrobiotamicrofloramouse modelmultispecies consortiamurine modelnovelpathogenpathwaypharmacologicpolyposisprogenitorprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationprogramspulmonary damagepulmonary functionpulmonary injurypulmonary repairpulmonary tissue damagepulmonary tissue injuryreceptorregenerate epitheliumregeneration pathwayregenerativerespiratory inflammationrespiratory injuryrespiratory progenitorrespiratory stem cellrespiratory tract epitheliumrespiratory tract inflammationrespiratory tract injuryresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor cell populationstem cell poolstem cell populationstem cells in the airwaytaste receptortranscription factortranscriptome sequencingtranscriptomic sequencingwindpipewound healingwound recoverywound resolution
Description preview
PROJECT SUMMARY
Tuft cells are a specialized epithelial cells (EpCs) that initiate airway type 2 inflammation (T2I) through their
generation of IL-25 and pro-inflammatory lipid mediators, cysteinyl leukotrienes (CysLTs). We previously
reported that airway tuft cells are indirectly activated by common aeroallergens through damage-associated…
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