grant
TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodeling
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Apr 2018Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025(TNF)-α0-11 years old21+ years oldAdultAdult HumanAffectAllergensAllergicAllergic DiseaseAnimalsAntigensAppetiteAtopic DermatitisAtopic EczemaAtopic NeurodermatitisBiopsyBlood EosinophilBlood monocyteBody TissuesCCL11CCL11 geneCCL2CCL2 geneCCL5CachectinCell BodyCell Communication and SignalingCell SignalingCellsChemoattractantsChemokine (C-C Motif) Ligand 5Chemokine, CC Motif, Ligand 2Chemotactic FactorsChemotaxinsChildChild YouthChildren (0-21)ChronicClinicalComplexCutaneous DisorderD17S136EDataDeglutitionDeglutition DisordersDependenceDermatosesDesire for foodDietDiseaseDisease ResistanceDisorderDisseminated NeurodermatitisDysfunctionDysphagiaEmesisEndoscopyEosinophilic EsophagitisEosinophilic GranulocyteEosinophilic LeukocyteEsophageal TissueEsophagitisEsophagusExhibitsExtracellular ProteinFailure to ThriveFamily memberFibroblastsFibrosisFoodFoundationsFunctional disorderGene ExpressionGene TranscriptionGenesGenetic TranscriptionGrantHVEMHealth Care CostsHealth CostsHouse Dust MitesHousedust MitesHumanIL-13IL13ImmuneImmune Cell ActivationImmunesIn VitroIncidenceInfiltrationInflammationInflammatoryInterleukin-13Intracellular Communication and SignalingInvestigatorsInvoluntary MuscleLIGHT proteinLightLong-term cohortLongitudinal cohortMCAFMCP-1MCP1MGC17164MGC22554Macrophage-Derived TNFMarrow EosinophilMarrow monocyteMeasuresMediatingMiceMice MammalsModelingModern ManMonitorMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMonocyte-Derived TNFMurineMusMyelogenousMyeloidMyofibroblastOralOrganPathogenicityPatientsPersonal SatisfactionPersonsPhenotypePhotoradiationPhysiopathologyPrevalenceProliferatingPropertyProteinsPsoriasisPyroglyphidaeRANTESRNA ExpressionReceptor ProteinRecurrenceRecurrentResearch PersonnelResearchersRoleSCYA11SCYA2SCYA5SIS deltaSIS-deltaSISdSequential TreatmentSeveritiesSignal TransductionSignal Transduction SystemsSignalingSkin DiseasesSkin Diseases and ManifestationsSmall Inducible Cytokine A2Small Inducible Cytokine A5Smooth MuscleSwallowingSwallowing DisordersT-Cell RANTES ProteinT-Cell Specific Protein p288T-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsTCP228TNFTNF ATNF AlphaTNF geneTNF-αTNFATNFSF14 gene productTNFαTechniquesTestingTherapeuticTherapeutic EffectTherapeutic InterventionTissue ProcurementsTissuesTopical CorticosteroidsTranscriptTranscriptionTumor Necrosis FactorTumor Necrosis Factor-alphaVomitingadulthoodaeroallergensairborn allergenairborne allergenallergic dermatitisallergic eczemabiological signal transductioncomplement chemotactic factorcutaneous diseasecytokinedermal diseasedermal disorderdietsdysmotilitydysmotility syndromeendoscopic imagingeosinophilfeedingfood Ingestionfood consumptionglobal gene expressionglobal transcription profilehigh voltage electron microscopyimmune activationimmunogenimprintin vivoindexingintervention therapykidsknock-downknockdownmembermonocytemotility disordermouse modelmurine modelmuscle hypertrophynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathophysiologyperiostinpre-clinicalpre-clinical studypreclinicalpreclinical studyprotein expressionpsoriasiformpsoriaticreceptorrecruitresistance to diseaseresistant diseaseresistant to diseaseresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskin disordersocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssynergismtherapeutic targetthymus derived lymphocytetranscriptomewell-beingwellbeingyoungster
Description preview
ABSTRACT
Eosinophilic Esophagitis (EoE) is an oral- and aero-antigen mediated allergic disease of increasing prevalence
and incidence. EoE is characterized by esophageal fibrosis, rigidity, and smooth muscle hypertrophy, resulting
in food impactions and strictures, vomiting, poor appetite, failure to thrive, and dysphagia. Chronic Th2-type…
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