grant
Tunable Surface Coatings to Control Protein Dynamics and Attenuate the FBR
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 5 Feb 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AdsorptionAttenuatedAutomobile DrivingBiocompatible MaterialsBiomaterialsBloodBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBody TissuesCapsulesCell BodyCellsChemicalsChemistryCold-Insoluble GlobulinsComplexEnvironmentEventFN1Fibronectin 1FibronectinsForeign BodiesGoalsHomolog of Drosophila TOLLHumanHydrophobicityImmuneImmunesImmunologyImplantIn VitroInflammatoryKO miceKnock-out MiceKnockout MiceKnowledgeLETS ProteinsLarge External Transformation-Sensitive ProteinLinkLiquid substanceMachine LearningMacrophageMacrophage ActivationMarrow NeutrophilMeasurementMediatingMedical DeviceMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMethodsModern ManMolecularMolecular Dynamics SimulationMyeloid Cell ActivationMyeloid CellsMφNatureNeutrophilic GranulocyteNeutrophilic LeukocyteNull MouseOpsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOutcomePaintPatternPolymersPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProcessProductionProfibrotic factorProfibrotic signalProtein DynamicsProtein EngineeringProteinsRNA SeqRNA sequencingRNAseqResearchRoleSerum ProteinsSignal PathwaySurfaceSurface ProteinsTIL4TLR proteinTLR2TLR2 geneTLR2 receptorTLR4TLR4 geneTestingTissuesToll HomologueToll-Like Receptor 2Toll-Like Receptor Family GeneToll-like receptorsToll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4Workalpha 2-Surface Binding Glycoproteinattenuateattenuatesbiocompatibilitybiological materialbiomaterial compatibilitybiomaterial developmentbiomaterial interfacecapsulecartilage link proteinclinical relevanceclinical translationclinically relevantclinically translatablecopolymerdrivingfluidgenetic protein engineeringhydrophilicityimplant coatingimplantationimprovedin vivoinnovateinnovationinnovativeinterdisciplinary approachinterfaciallink proteinliquidmachine based learningmolecular dynamicsmouse modelmultidisciplinarymultidisciplinary approachmurine modelmutantneutrophilnovelpolymerpolymericpreventpreventingprotein complexprotein designprotein foldingresponsesimulationsingle moleculesocial rolesurface coatingtoll-like receptor 4transcriptome sequencingtranscriptomic sequencing
Description preview
The foreign body response (FBR) induced by the implantation of synthetic biomaterials remains a formidable
challenge. The FBR begins as an inflammatory process that is mediated by innate immune cells and culminates
in the production of an avascular fibrous capsule. While the FBR has been extensively studied, a detailed
understanding of the…
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